中风1号汤对急性高血压性脑出血的影响临床研究

目的:研究急性脑出血(AICH)可能存在的治疗时间窗及中风1号汤(ZF1H)的干预作用。方法:将3 67例急性脑出血患者随机分为2组,基础治疗均采用西医常规疗法,治疗组187例加用中风1号汤口服,对照组180例。主要观察治疗后3 0天的病死率、使用ZF1H 3 0天后统计凝血功能(PT ,APTT)的影响、残疾程度(GOS)及哥拉斯哥昏迷量表(GCS)的影响。结果:治疗组治愈率、总有效率均高于对照组,2组比较,差异均有显著意义(P <0 0 5 )。ZF1H可以降低对照组AICH患者3 0d的病死率。结论:中风1号汤可以降低AICH患者3 0d病死率,提高GCS评分,改善临床症状,减少并发症,病死率和致残率,提高生活质量。

A Clinical study of the influence of zhong feng 1hao oral liquid (ZF1H) to AICH

Objection:to study the intervention of Zhongfen 1hao.Method:(1)Retrospectively analyze the two AICH randomized clinical trail from 1998-2004,sub-groups differentiating according the time from onset to the first treatment.(2) We divided into 0-6h,6-24h,24-48h,48-72h,the baseline data include sex,age,blood pressure,medical history scale,concomitant disease scale,Glasgow Coma Scale (GCS).(3) The endpoints include mortality rate,NIHSS,Glasgow Outcome Scale(GOS),Barthal Index (BI).(4)Analyze the hematoma enlargement after ZF1H treatment.Results:(1)Total patient sample is 367,including 187 ZF1H and 181 control.(2) in the baseline data have not significant difference between ZF1H and control group except systolic blood pressure (SBP),diastolic blood pressure (DBP) and mean arterial prssure (MAP) to 48-72h.(3) In the time window from 0 to 72hrs.In the time window from 48 to 72hrs.(4) ZF1H was able to decrease the prothrombin time (PT),no evidence showed that ZF1H was able toincrease the hematoma enlargement.Conclusions:(1) 72hrs is a acceptable therapeutic time window.(2) ZF1H should be used after the AICH onset as soon as possible.(3) We should not treat the hypertension after AICH too positively,unless they have strong accommodation.