| 健康人体内甲磺酸加替沙星对茶碱稳态药代动力学的影响 |
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| 引用本文： | 朱 华,贾玲昌,倪 立,芮建中,孙礼琴,许建国.健康人体内甲磺酸加替沙星对茶碱稳态药代动力学的影响[J].药学与临床研究,2011,19(5):423-425. |
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| 作者姓名： | 朱 华 贾玲昌 倪 立 芮建中 孙礼琴 许建国 |
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| 作者单位： | 1. 苏北人民医院,扬州,225001
2. 南京军区南京总医院,南京,210002 |
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| 基金项目： | 江苏省卫生厅科研项目奥赛康临床药学研究基金 |
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| 摘 要： | 目的:研究甲磺酸加替沙星对健康人体内茶碱稳态药代动力学的影响。方法:采用HPLC法测定健康人体单独给药和合并甲磺酸加替沙星给药后茶碱的血药浓度,采用3P97药动学软件处理,选用非参数法计算药动学参数,Cmax和Tmax为实测值,AUC采用梯形法计算曲线下积分面积。主要药动学参数采用SPSS11.5软件进行统计分析。结果:单用和合用甲磺酸加替沙星后,茶碱的药动学参数Cmax、t1/2、CL、AUC0-12、AUC0-∞之间有显著性差异(P<0.01)。Cmax明显下降,t1/2明显减小,AUC0-12与AUC0-∞明显下降。结论:甲磺酸加替沙星对健康人体内茶碱稳态药动学有影响,两者合用可能降低茶碱疗效,提示两药合用应监测茶碱的血药浓度。
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| 关 键 词： | 甲磺酸加替沙星 茶碱 药代动力学 HPLC法 |
| 收稿时间： | 2011/6/13 0:00:00 |
| 修稿时间： | 2011/7/25 0:00:00 |
Influence of Gatifloxacin on Pharmacokinetics of Theophylline at Steady State in Healthy Volunteers |
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| ZHU Hu,JIA Ling-chang,NI Li,RUI Jian-zhong,SUN Li-qin and XU Jian-guo.Influence of Gatifloxacin on Pharmacokinetics of Theophylline at Steady State in Healthy Volunteers[J].Pharmacertical and Clinical Research,2011,19(5):423-425. |
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| Authors: | ZHU Hu JIA Ling-chang NI Li RUI Jian-zhong SUN Li-qin and XU Jian-guo |
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| Institution: | ZHU Hua1,JIA Ling-chang1,NI Li2,RUI Jian-zhong2,SUN Li-qin1,XU Jian-guo1 1Subei People's Hospital,Yangzhou 225001,China,2Nanjing General Hospital of Nanjing Military Commard,Nanjing 210002 |
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| Abstract: | Objective: To study the effect of gatifloxacin on pharmacokinetics of theophylline in healthy volunteers.Methods: The concentration of theophylline in plasma was detected by high performance liquid chromatography(HPLC) before and after gatifloxacin administration.Pharmacokinetic parameters were evaluated by the 3P97 pharmacokinetics program.Statistical analysis was performed with the SPSS11.5 software.Results: After theophylline was used alone and in combination with gatifloxacin,the pharmacokinetic process... |
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| Keywords: | Gatifloxacin mesylate Theophylline Pharmacokinetics HPLC |
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