难治性抑郁症相关炎症机制的研究进展

抑郁症是一种危害全球人类生活质量的精神疾病,具有高患病率、高疾病负担、高致残率的特点。目前有许多针对单胺递质的抗抑郁药物可供使用,然而,大约有三分之一的患者在进行基于多种单胺疗法的充分治疗后仍然不能治愈。此类疾病在临床上被称为难治性抑郁症。该疾病的具体病理生理机制尚未明确,但随着抑郁症的炎症机制不断被大众认可,难治性抑郁症的神经炎症也备受关注。本文将从炎症的角度对难治性抑郁症的发病机制进行综述,为其下一步的深入研究提供思路与方向。

Inflammatory mechanism of treatment-resistant depression: research progress

Depression is a kind of mental illness that endangers the quality of life among human beings all over the world. It has the characteristics of high morbidity rate, high burden of disease and high disability rate. Despite the availability of several antidepressants targeting monoamine transmitters, nearly a third of patients fail to respond to treatment after adequate treatment based on multiple monoamine therapies. The condition is clinically known as treatment-resistant depression. At present, the specific pathophysiological mechanism of the disease is not clear, but with the increasing recognition of the inflammatory mechanism of depression, the neuroinflammation of treatment-resistant depression has attracted much attention. This paper will review the pathogenesis of refractory depression from the perspective of inflammation and provide ideas and directions for further research.