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Major Hepatectomy Is a Safe Modality for the Treatment of Intrahepatic Cholangiocarcinoma in Selected Patients Complicated with Cirrhosis |
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| Authors: | Hao Li Jin-shu Wu Xin-tian Wang Pin Lv Gang Liu Bu-ning Tian Ya-yong Li Dao-jin Chen Bo Jiang |
| Affiliation: | 1. Department of Hepatobiliary Surgery, Hunan Provincial People’s Hospital, No.253 of Jiefang Road, Changsha, 410002, People’s Republic of China 2. National Hepatobiliary and Enteric Surgery Research Center, Ministry of Health, Xiangya Hospital, Central South University, Changsha, 410008, China 3. Department of General Surgery, Third Xiangya Hospital of Central South University, Changsha, 410013, China |
| Abstract: | ObjectiveThe objective of this paper is to evaluate the perioperative outcomes of major hepatectomy for intrahepatic cholangiocarcinoma (ICC) in patients with cirrhosis.MethodsWe retrospectively evaluated the preoperative, intraoperative, and postoperative findings in 42 consecutive patients with cirrhosis and in 102 patients with normal livers who underwent major hepatectomy for ICC.ResultsPreoperative liver function was worse in patients with cirrhosis compared to patients without cirrhosis. Cirrhotic patients had significantly higher intraoperative blood loss, longer operation time, and longer hospital stay than non-cirrhotic patients. However, the two groups had similar overall morbidity and hospital mortality rates and similar rates of liver failure or other complications. Their R0 resection rates, resection margin widths and disease-free survival rates were also similar.ConclusionsMajor hepatectomy for ICC can be performed in selected cirrhotic patients with acceptable morbidity and mortality rates, as compared to patients without cirrhosis. |
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