肝硬化患者交感肾上腺系统肾血流动力学与钠潴留的关系

本研究表明肝硬化腹水患者有明显的钠潴留，肾血流量和肾小球滤过率下降；血浆去甲肾上腺和肾上腺素的浓度及其从尿中的排除量显著增加，并与有效肾血浆流量、内生肌酐清除率及24h尿钠量呈密切负相关，提示在肠硬化腹水患者，交感肾上腺系统系统的活动增强是肾血流动力学异常和钠潴留的重要因素。

THE RELATIONSHIP OF SYMPATHETIC-ADRENAL SYSTEMAND RENAL HEMODYNAMICS IN CIRRHOSIS TOSODIUM RETENTION

The sympath etic-adrenal system and renal hemody-namics in relation with sodium retention were studied in cases with and 20 cases without ascites and 35 cases of normal con-trol. Our results showed that there is a significant sodium retention in the bodies of patients with cirrhosis and ascites, the renal dlood flow and glomerular filtration rate decreased; Both plasma-noradrenaline and adrenaline concentration were significantly increased, and so did the urinary excretion of th em. Except this, they were negatively correlated with the effective renal plasma flow, endogenous creatinine clearance rate and urinary sodium excretion in 24 hours. It suggested that the enhanced activity of sympathetic adrenal system waa playing an important role in the abnormalities of renal hemodynam ics and sodium retention in patients with cirrhosis and ascites.