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| 肺癌患者外周血CD4+T淋巴细胞Th1/Th2分化情况检测与分析 | |
| 引用本文： | 白澎,张沪生,王毓洲. 肺癌患者外周血CD4+T淋巴细胞Th1/Th2分化情况检测与分析[J]. 首都医科大学学报, 2006, 27(1): 17-19 |
| 作者姓名： | 白澎 张沪生 王毓洲 |
| 作者单位： | 首都医科大学附属北京同仁医院呼吸内科;北京协和医院肿瘤科 |
| 摘 要： | 目的观察肺癌患者外周血CD4+T淋巴细胞中Th1/Th2分化情况与反应状态,为肺癌的诊断和免疫治疗研究提供依据。方法以干扰素-γ(IFN-γ)和白细胞介素-4(IL-4)代表Th1和Th2细胞功能,应用细胞因子诱生技术和流式细胞仪,检测25例肺癌患者及25例健康志愿者外周血CD4+T淋巴细胞诱生的IFN-γ和IL-4水平。结果肺癌患者外周血CD4+T淋巴细胞诱生的IFN-γ水平与健康对照组比较明显降低,差异有统计学意义(P<0.05),IL-4水平在2组间差异无统计学意义(P>0.05)。结论肺癌患者外周血CD4+T淋巴细胞向Th1细胞的分化明显减少,向Th2细胞的分化无明显变化,Th1向Th2方向的漂移可能是肺癌细胞生长和免疫逃避的机制之一。 |
| 关 键 词： | 肺肿瘤 Th1/Th2细胞 白细胞介素-4 干扰素 |
| 收稿时间： | 2005-12-16 |
| 修稿时间： | 2005-12-16 |
The Differentiation of Th1 and Th2 CD4+ T Lymphocytes of Peripheral Blood from Lung Cancer Patients |
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| Bai Peng,Zhang Husheng,Wang Yuzhou. The Differentiation of Th1 and Th2 CD4+ T Lymphocytes of Peripheral Blood from Lung Cancer Patients[J]. Journal of Capital Medical University, 2006, 27(1): 17-19 | |
| Authors: | Bai Peng Zhang Husheng Wang Yuzhou |
| Affiliation: | 1. Department of Respiratory Diseases, Beijing Tongren Hospital, Capital University of Medical Sciences ; 2. Department of Oncology, Peking Union Medical College Hospital |
| Abstract: | Objective To evaluate the differentiation of Th1 and Th2 CD4+ T lymphocytes of peripheral blood from lung cancer patients.Methods Interferon-γ(IFN-γ) and interleukin-4(IL-4) levels in CD4+ T lymphocytes of peripheral blood from 25 lung cancer patients and 25 healthy volunteers were detected using flow cytometry.IFN-γand IL-4 were used as markers for the differentiation of Th1 and Th2 subsets,respectively.Results IFN-γwas lower in CD4+ T lymphocytes from lung cancer patients than that from healthy controls.No difference was found for IL4.Conclusion The ratio of Th1 to Th2 subsets changed in lung cancer patients,which may be one of the mechanisms for the tumor to escape from the immune surveillance. |
| Keywords: | lung cancer Th1/Th2 cells IL-4 IFN-γ |
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