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| 正交试验优选腰痛宁颗粒提取工艺 | |
| 引用本文： | 孙学惠,史国兵,安晔,孙燕,王常丽,张磊. 正交试验优选腰痛宁颗粒提取工艺[J]. 中国药师, 2012, 15(6): 850-852 |
| 作者姓名： | 孙学惠 史国兵 安晔 孙燕 王常丽 张磊 |
| 作者单位： | 沈阳军区总医院,沈阳,110016 |
| 摘 要： | 目的:优选乙醇提取腰痛宁颗粒工艺.方法:采用正交试验法,以绿原酸、芍药苷、大黄素为综合评分指标,以乙醇浓度、溶剂量、提取时间、提取次数为考察因素,各设置3个水平,对腰痛宁颗粒乙醇提取工艺进行优化.结果:腰痛宁颗粒的最佳提取工艺条件为12倍量70%乙醇,回流提取3次,每次1.5 h.结论:优选的提取工艺对各指标性成分的提取率均较高,可为制剂生产提供依据. |
| 关 键 词： | 绿原酸 芍药苷 大黄素 提取工艺 正交试验 |
| 收稿时间： | 2012-01-07 |
| 修稿时间： | 2012-03-01 |
Optimization of Extraction Technology of Yaotongning Granules by Othogonal Experimental Design with Multi-indices |
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| Sun Xuehui,Shi Guobing,An Ye,Sun Yan,Wang Changli and Zhang Lei. Optimization of Extraction Technology of Yaotongning Granules by Othogonal Experimental Design with Multi-indices[J]. China Pharmacist, 2012, 15(6): 850-852 | |
| Authors: | Sun Xuehui Shi Guobing An Ye Sun Yan Wang Changli Zhang Lei |
| Affiliation: | (Department of Pharmacy,General Hospital of Shenyang Military District,Shenyang 110016,China) |
| Abstract: | ABSTRACT Objective: To optimize the extraction technology of Yaotongning granules. Method:The contents of chlorogenic acid, paeoniflorin and emodin, and the extract yield were used as the analysis indices. The extraction technology was optimized by orthogonal experimental design with alcohol concentration, solvent volume, extraction time and the number of extraction times as the factors. Result:The optimized extraction technology was as follows: extracted 3 times with 12-fold 70% alcohol,1.5 h each time.Conclusion:The extraction technology shows higher efficiency for each indicated component and can provide the basis for the mass production. |
| Keywords: | Chlorogenic acid Paeoniflorin Emodin Extraction technology Orthogonal experimental design |
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