大鼠失血性休克和回输血后重要器官组织脂质过氧化及腺苷酸代谢变化

作者观察到大鼠失血性休克早期各脏器（小肠、肺、肝）ＭＤＡ含量变化不显著，甚或有减少（心、肾）；回输血后除肺外，其它脏器ＭＤＡ含量均显著增加。心、肝、肾组织ＡＴＰ及能荷回输血后仍低于对照组；ＳＯＤ、ＣＡＴ预处理后各脏器ＭＤＡ含量均显著减少，心、肝、行组织ＡＴＰ、能荷显著升高。结果提示：失血性休克回输血后多个器官组织氧自由基产生增加，能量代谢恢复亦发生障碍。ＳＯＤ、ＣＡＴ治疗可降低组织脂质过氧化反应，促进能量代谢的恢复。

Studies on lipid peroxide and adenine nucleotide levels in main organ tissues of rats following hemorrhagic shock and reperfusion

The animals were divided into five groups: control group, shock group, reperfusion group, SOD and CAT pretreatment group. The results showed that in shock group the MDA content of heart and kidney were significantly decreased but not much changes was found in others (bowel,lung, and liver).In reperfusion group, the content of MDA were elevated significantly. In SOD and CAT pretreatment group, the content of MDA were decreased significantly.In shock group and reperfusion group ATP and energy charge(EC) in heart, kidney and liver were significantly decreased. In both SOD and CAT pretreatment group, ATP and EC were significantly increased. These results indicated that production of oxygen free radicals may occur in main organs during reperfusion. These radicals, through augmenting membranes lipid peroxidation and effecting energy metablism, might participanted in the pathogenesis of reperfusion damage after hemorrhagic shock.