|
|||||
|
|
| 三丁基锡暴露可使大鼠脑乙酰胆碱酯酶活性升高 | |
| 引用本文： | 朱欣,连灵君,王燕,刘慧刚,徐立红. 三丁基锡暴露可使大鼠脑乙酰胆碱酯酶活性升高[J]. 癌变．畸变．突变, 2006, 18(4): 292-293 |
| 作者姓名： | 朱欣 连灵君 王燕 刘慧刚 徐立红 |
| 作者单位： | 浙江大学劳动卫生与环境卫生研究所,浙江,杭州,310031;浙江大学劳动卫生与环境卫生研究所,浙江,杭州,310031;浙江大学医学院生物化学与分子生物学教研室,浙江,杭州,310031 |
| 基金项目： | 国家自然科学基金(No.20137010) |
| 摘 要： | 背景与目的:检测三丁基锡(Tributyltin,TBT)对大鼠脑乙酰胆碱酯酶(AChE)活性的影响,探讨AChE与TBT毒性作用的关系。材料与方法:SD大鼠共48只随机分为4组,每组12只,分别为对照组(0mg/kgTBT)和3个实验组(0.1、1、10mg/kgTBT),对大鼠进行灌胃染毒,在第4、8、12d时分别于各组中取4只大鼠的脑组织,测定AChE水平。结果:TBT能够引起大鼠脑AChE活性升高,随染毒剂量的升高和暴露时间的延长AChE活性升高趋势增强。结论:TBT诱导大鼠脑AChE活性升高可能与TBT的神经毒性相关。 |
| 关 键 词： | 三丁基锡 乙酰胆碱酯酶 神经毒性 |
| 文章编号： | 1004-616X（2006）04-0292-02 |
| 收稿时间： | 2005-07-13 |
| 修稿时间： | 2005-11-02 |
Tributyltin Exposure Leads to Acetylcholinesterase Activity Elevation in Rat Brain |
|
| ZHU Xin,LIAN Ling-jun,WANG Yan,LIU Hui-gang,XU Li-hong. Tributyltin Exposure Leads to Acetylcholinesterase Activity Elevation in Rat Brain[J]. Carcinogenesis,Teratogenesis and Mutagenesis, 2006, 18(4): 292-293 | |
| Authors: | ZHU Xin LIAN Ling-jun WANG Yan LIU Hui-gang XU Li-hong |
| Affiliation: | 1. Institute of Occupational and Environmental Health, Zhefiang University Hang zhou 3100031, Zhejiang, China; 2.Department of Biochemistry and Molecular Biology, School of Medicine, Zhejiang University, Hangzhou 310031, Zhejiang, China |
| Abstract: | BACKGROUND&AIM: The study investigated the effect of tributyltin(TBT)on the activities of acetylcholinesterase(AChE)in brain of rats.The possible relationship between AChE and the toxicity of TBT was discussed. MATERIAL AND METHODS: 48SD rats were divided randomly into4groups,12rats in each group.Experimental groups received0.1,1or10mg/kg TBT by oral gavage and same volume olive oil was given to control group(0mg/kg TBT).The brain tissues were obtained from4rats in each group at the4th,8th and12th day and the AChE activities were measured. RESULTS: TBT exposure could lead to AChE activity elevation in rat brains,and in a dose_related and time_depending manner. CONCLUSION: The increase of AChE activity could possibly be related to the neurotoxicity of TBT. |
| Keywords: | tributyltin acetylcholinesterase neurotoxicity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |