0．1％他克莫司软膏联合毫米波治疗慢性非特异性唇炎的疗效评价及护理方法

目的：评价0．1％他克莫司软膏（ tacrolimus ointment）联合毫米波（ millimeter wave,MMW）治疗慢性非特异唇炎（ chronic cheilitis,CC）的临床疗效,并探讨相应的护理标准。方法：选择慢性非特异唇炎40例,按治疗方式分为3组,0．1％他克莫司软膏治疗组、毫米波治疗组和0．1％他克莫司软膏治疗与毫米波治疗联合治疗组。严格按照拟定的治疗方案对各组患者进行治疗,7 d为一疗程,在第7 d和第14 d分别评价各组患者的治疗效果。结果：联合组与0．1％他克莫司软膏治疗组疗效均优于毫米波治疗组（P＜0．05）,且两者在第14 d疗效并无显著差异。但是在第7 d时,联合治疗组的疗效优于0．1％他克莫司软膏组（P＜0．05）,且联合治疗组在第7 d与第14 d的疗效差异无统计学意义。结论：联合使用毫米波虽不能有效提高0．1％他克莫司软膏对于慢性非特应性唇炎的治疗效果,但能缩短治疗时间、减少用量,从而降低0．1％他克莫司软膏的副作用。

The efficacy evaluation and nursing standard for managements of chronic cheilitis using 0.1%tacrolimus oint-ment combined with millimeter wave therapy

Objective:To assess the efficacy of a combined management for chronic cheilitis(CC)with 0.1%tacroli-mus ointment and millimeter wave( MMV) and set up a nursing standard for CC.Methods:Forty CC patients were divided in-to 3 group(0.1%tacrolimus ointment group,MMV group,and combined treating group) according to different treatments.Af-ter 7 and 14 days,all CC patients were evaluated with investigators global assessment( IGA) .Results:The efficacy evaluation of 0.1%tacrolimus ointment group and combined treating group were significantly better than MMV group(P<0.05).How-ever,at the end of 7 days,combined treating group was superior to 0.1% tacrolimus ointment group(P<0.05),and there
was no statistically significant difference between the two assessment for combined treating group.Conclusion:In current study,0.1%tacrolimus ointment and MMW were used combined to treat CC,and the therapeutic evaluation represented no obvious improvement compared with 0.1% tacrolimus used alone.However, it seemed to be meaningful in shortening the treatment length and decrease the dosage of tacrolimus ointment,which might alleviate the side effect of tacrolimus ointment like hyperpigmentation in the lips.