沙利度胺对复发性阿弗他溃疡患者外周血淋巴细胞亚群的影响

目的：观察沙利度胺对复发性阿弗他溃疡（ RAU）患者外周血淋巴细胞亚群的影响及治疗疗效。方法：选择轻型RAU患者（轻型RAU组）85例，健康对照组80例，随访观察服用沙利度胺25 mg／d治疗轻型RAU的疗效；同时比较健康对照组，轻型RAU组治疗前后外周血淋巴细胞亚群检测结果。结果：和健康对照组相比，轻型RAU患者CD4＋T淋巴细胞数目减少，CD8＋T淋巴细胞增多，淋巴细胞亚群比例失调；经沙利度胺治疗后，轻型RAU患者淋巴细胞亚群比例异常改善，同时患者溃疡间歇期明显延长，溃疡数目明显减少，差异均具有统计学意义（P＜0．05）。结论：轻型RAU患者存在外周血T淋巴细胞亚群比例异常，沙利度胺可有效调节CD4＋、CD8＋T淋巴细胞亚群比例，延长溃疡间歇期，减少溃疡发作，临床疗效满意。

Observation the effect of Thalidomide treatment of recurrent aphthous ulcers on peripheral lymphocyte popula-tions

Objective:To observe the clinical efficacy of Thalidomide in the treatment of Recurrent Aphthous Ulcers ( RAU) and its impact on subsets of lymphocytes in the peripheral circulation.Methods:Thalidomide was administered to 85 patients with RAU minor at 25 mg per day.The clinical effect was measured by comparing the remission time and the number of ulcers pre-and post-intervention.Meanwhile,the total number of peripheral lymphocytes and the ratio of CD4 +T cell to CD8 +T cells were measured before and after the intervention compared with the control group consisted of health partici-pants.Results:Compared to the control group,there was a significant decrease of CD4 +T cells and increase of CD8 +T cells (P<0.05)in the patients with RAU minor before the treatment.The ratio of the two subsets was also abnormal.After the in-tervention,the ratio of the lymphocyte subsets was improved.Meanwhile,there was a significant increase in the remission time of the ulcers and reduced in the number of ulcers in patient group(P<0.05).Conclusion:The ratio of the peripheral lym-phocyte subsets is abnormal in patients with RAU.Thalidomide has a significant effect in correcting the abnormal ratio of CD4 +T cells to CD8 +T cells.It can also increase the remission time of ulcers and reduce the frequency of ulcer breakouts. The clinical efficacy has been satisfactory.