抑郁障碍患者的认知功能损害及相关因素分析

目的:探索抑郁障碍患者认知功能损害的特点,以及与临床特征和症状严重程度的关系。方法:采用成套神经认知测试系统(CANTAB)对90例抑郁障碍患者及100例健康对照者进行认知功能测试,包括视觉记忆、持续注意、工作记忆与执行功能。结果:患者组所有认知功能与对照组相比,差异有统计学意义(P0.05)。抑郁发作次数与视觉记忆、持续注意负相关(P0.01);单次抑郁发作持续时间与持续注意、执行功能负相关(P均0.01)。汉密尔顿抑郁量表的认知障碍因子与视觉记忆负相关(P均0.01);焦虑/躯体化因子、阻滞因子与持续注意负相关(P均0.05)。结论:抑郁障碍患者存在广泛的认知功能损害,临床特征和症状严重度对认识功能损害存在差异性的影响。

The study of cognitive impairment in patients with major depressive disorder and correlation with clini-cal features

Objective: To explore the cognitive impairment in patients with major depressive disorder, and analyze the influencing factors. Method:90 major depressive disorder patients and 100 control subjects were assessed with the Cambridge neuropsychological test automated battery(CANTAB). The visual memory, sustain attention,working memory and executive function were measured. Results:Major depressive disorder patients displayed impairment in visual memory,sustain attention,working memory and executive function(P<0. 05). The time of depressive episode was negatively correlated with visual memory and sustain attention (P<0. 01),the duration of depression was negatively correlated with sustain attention and executive function ( P<0.01). Anxiety/Somatization factor and retardation factor were negatively related with sustain attention(P<0. 01),cognitive impairment factor was negatively related with visual memory(P<0. 05). Conclusion:major depressive disorder has extensive cognitive function impairment,which were correlated with clinical features and symptom respectively.