| 格林—巴利综合征相关空肠弯曲菌脂多糖抗原初步分析 |
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| 引用本文： | 张建中,李春岩.格林—巴利综合征相关空肠弯曲菌脂多糖抗原初步分析[J].中华微生物学和免疫学杂志,1997,17(2):79-81. |
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| 作者姓名： | 张建中 李春岩 |
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| 作者单位： | 中国预防医学科学院流行病学微生物学研究所，河北医科大学第二附属医院 |
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| 摘 要： | 用格林－巴利综合征相关性空肠弯曲菌复制动物模型成功后的动物免疫血清对河北省格林－巴利综合征病人分离株空肠弯曲菌、动物来源株空肠弯曲菌及北京对照用人源株空肠弯曲菌及其脂多糖抗原性进行分析。结果显示，发生了典型的格林－巴利综合征样疾病的动物已产生了明显的抗格林－巴利综合征相关性空肠弯曲菌的免疫反应，其抗脂多糖抗体与当地其它来源株空肠弯曲菌有部分交叉反应，与北京分离株空肠弯曲菌无明显交叉反应。说明格林－巴利综合征相关性空肠弯曲菌脂多糖具有其独持的抗原性。支持某些特殊血清型的空肠弯曲菌参与格林－巴利综合征的致病过程。
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| 关 键 词： | 多神经根神经炎 弯曲杆菌.空肠 脂多糖类 |
studies on the LPS antigens of the Guillain Barre syndrome associated Campylobacter jejuni |
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| Zhang Jianzhong ,Li Chunyan,Chen Jingjing,et al..studies on the LPS antigens of the Guillain Barre syndrome associated Campylobacter jejuni[J].Chinese Journal of Microbiology and Immunology,1997,17(2):79-81. |
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| Authors: | Zhang Jianzhong Li Chunyan Chen Jingjing |
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| Institution: | Zhang Jianzhong *,Li Chunyan,Chen Jingjing,et al. *Institute of Epidemiology and Microbiology,Chinese Academy of Preventive Medicine,Beijing 102206 |
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| Abstract: | Lipopolysaccharides (LPS) antigens differences between the Guillain Barre syndrome associated C.jejuni and Non Guillain Barre syndrome associated C.jejuni were studied by using the SDS PAGE and Western blots analysis.The results indicated that the anti LPS antibodies reacted partially with the local C.jejuni strains,but get no reaction with the strains isolated from Beijing district.The LPS of Guillain Barre syndrome associated C.jejuni has specifically antigenicity,and the corresponding serum type of C.jejuni might be the real pathogen of Guillain Barre syndrome. |
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| Keywords: | Polyradiculon euritis Campylobacter jejuni Lipopolysaccharides |
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