病毒性心肌炎患者血清sIL-2R、IL-6和IL-8水平变化及临床意义

作者观察了50份柯萨基B组病毒（Cox B）性心肌炎患者血清IL-6、 IL-8和sIL-2R的水平变化,及与病毒血症的关系。发现病毒性心肌炎患者血清的IL-8和IL-6水平均显著高于正常对照组,其中血清Cox B抗原和特异性IgM抗体均阳性组（20例）的IL-8和IL-6含量均明显高于仅检出特异性IgM抗体组（30例）,且IL-8含量升高的程度与检测抗原的阳性强度是显著正相关。然而,两组间及与正常对照组间sIL-2R的含量均无明显差异。认为血清IL-8水平升高是病毒性心肌炎急性期的一个重要指标,并间接反映机体处于病毒血症或病毒抗原血症。

Changes of Serum SIL-2R, IL-6 and IL-8 Levels in Patients with Viral Myocarditis and Their Clinical Significances

To evaluate the relationship between viremia and cytokines in patients with viral myocarditis, levels of serum sIL-2, IL-6 and IL-8 were observed in sera from patients with Coxsackie B viral myocarditis. It was found that levels of serum IL-6 and IL-8 were significantly higher in patients with mocarditis than in normal controls. Patients with positive Cox B antigen and specific IgM antibody had significantly higher levels of IL-6 and IL-8 than cases only with positive IgM antibody, A significantly positive correction existed between elevation in IL-8 content and positive rate of detectable antigens, but the contents of sIL-2R had no significant difference among sera from two myocarditis groups and from normal controls. The results indicated that elevation of IL-8 serum levels might be an important marker for the acute phase of viral myocarditis, indirectly reflecting the presence of viremia or viral antigenemia.