| 酮替酚对鸡蛋过敏特应性皮炎患儿淋巴细胞增殖反应的抑制作用 |
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| 引用本文： | 耿排力.酮替酚对鸡蛋过敏特应性皮炎患儿淋巴细胞增殖反应的抑制作用[J].现代免疫学,1997,17(4):228-231. |
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| 作者姓名： | 耿排力 |
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| 作者单位： | 青海医学院微生物免疫教研室，日本国立岐阜大学医学部 西宁810001 |
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| 摘 要： | 作者探讨了鸡蛋过敏特应性皮炎(AD)患儿外周血单个核细胞(PBMCs)对卵白蛋白(OA)刺激的增殖反应并观察了酮替酚(KF)对此反应的影响.结果提示AD患儿的PBMCs增殖反应显著高于健康儿童;KF可剂量依赖性地抑制鸡蛋过敏AD患儿PBMCs对OA刺激的增殖反应,且这一效应可通过KF抑制T细胞的作用而得以实现.KF对植物血凝素(PHA)和破伤风类毒素(TT)诱导的PBMCs增殖反应无抑制作用.这说明KF只抑制食物过敏AD患者PBMCs对食物抗原的特异性增殖反应.
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| 关 键 词： | 酮替酚(KF) 鸡蛋过敏特应性皮炎 淋巴细胞增殖反应 |
Suppressive Effects of Ketotifen Fumarate on Proliferative Responses of Lymphocytes in Patients with Food Sensitive Atopic Dermatitis |
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| Geng Paili,Naomi Kondo.Suppressive Effects of Ketotifen Fumarate on Proliferative Responses of Lymphocytes in Patients with Food Sensitive Atopic Dermatitis[J].Current Immunology,1997,17(4):228-231. |
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| Authors: | Geng Paili Naomi Kondo |
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| Institution: | Geng Paili,Naomi Kondo* |
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| Abstract: | In this study, the proliferative responses of peripheral blood mononuclear cells (PBMCs) to oval-bumin (OA) in children with atopic dermatitis (AD), who are sensitive to hen's egg, were significantly higher than those of healthy children. The proliferative responses of PBMCs to OA were dose-dependently inhibited by ketotifen and this inhibition was realized by the effects of ketotifen on T cells. In contrast, the proliferative responses of PBMCs to phytohemagglutinin and tetanus toxoid were not inhibited by ketotifen. These results suggest that ketotifen only inbibits food antigen-specific proliferative responses of PBMCs in patients with food sensitive AD. |
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| Keywords: | ketotifen atopic dermatitis lymphocytes proliferative responses inhibition |
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