载脂蛋白E基因敲除小鼠用于动脉粥样硬化研究的进展

载脂蛋白（apolipoprotein，ApoE）基因敲除小鼠是目前研究动脉粥样硬化发生发展机制的最为理想的动物模型之一，尤其是近年来，又成为易损斑块动物模型研究的热点。有关apoE^-I-小鼠动脉粥样硬化斑块病理特点、炎症在斑块破裂中的作用及对其干预治疗等研究，近来又有了许多新的发现。

Update on ApoE-knockout Mice for Atherosclerosis Research

ApoE-knockout mice are one of the best models for research on mechanism of atherosclerosis, which became a popular model used in studies on vulnerable plaques. Over the recent years there have been many considerable and exciting findings of pathologic characteristics of atherosclerotic plaques, role of inflammation in plaques disruption, and treatment in ApoE deficient mice, etc.