| 基于系统虚拟药理学复方丹参滴丸抗血小板聚集药效物质基础研究 |
| |
| 引用本文： | 马世堂,戴国梁,程小桂,赵文珠,孙冰婷,居文政,谈恒山. 基于系统虚拟药理学复方丹参滴丸抗血小板聚集药效物质基础研究[J]. 中药材, 2018, 0(1): 189-194 |
| |
| 作者姓名： | 马世堂 戴国梁 程小桂 赵文珠 孙冰婷 居文政 谈恒山 |
| |
| 作者单位： | 安徽科技学院食品药品学院;南京中医药大学药学院;南京中医药大学附属医院临床药理科;南京军区总医院临床药理科 |
| |
| 基金项目： | 国家自然科学基金(81403268;81403114);安徽省公益性技术应用研究联动计划(1704f0704062);安徽省教育厅人才基金(gxfx2017076);安徽科技学院稳定人才基金(SPWD201602) |
| |
| 摘 要： | 目的:基于系统虚拟药理学研究复方丹参滴丸抗血小板聚集药效物质基础,对该复方作用效应在分子网络层面上进行探析。方法:选择了16个血小板聚集相关靶点,构建该组方化学成分分子数据库,探讨数据库分子与血小板聚集靶点间相互作用关系。结果:该组方与16个血小板聚集靶点均有一定的潜在协同效应;并应用药理学实验对部分数据进行了验证。结论:本实验从分子层次上阐释了复方丹参滴丸抗血小板聚集系统药效物质基础,为该组方的临床应用提供了科学依据;同时,也为寻找血小板聚集药物提供一定的参考和借鉴。
|
| 关 键 词： | 复方丹参滴丸 系统虚拟药理学 药效物质基础 抗血小板聚集 |
The Systematical In-silico Pharmacology for Platelet Aggregation Inhibition of Compound Danshen Dripping Pill and Its Material Basis for Efficacy |
| |
| MA Shi-tang,DAI Guo-liang,CHENG Xiao-gui,ZHAO Wen-zhu,SUN Bing-ting,JU Wen-zheng,TAN Heng-shan. The Systematical In-silico Pharmacology for Platelet Aggregation Inhibition of Compound Danshen Dripping Pill and Its Material Basis for Efficacy[J]. Journal of Chinese medicinal materials, 2018, 0(1): 189-194 |
| |
| Authors: | MA Shi-tang DAI Guo-liang CHENG Xiao-gui ZHAO Wen-zhu SUN Bing-ting JU Wen-zheng TAN Heng-shan |
| |
| Affiliation: | (College of Food and Drug of Anhui Science and Technology University,Fengyang 233100,China;College of Pharmacy,Nanjing University of Traditional Chinese Medicine,Nanjing 210029,China;Department of Clinical Pharmacology,Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing 210029,China;Department of Clinical Pharmacology,General Hospital of Nanjing Military Area Command,Nanjing 210002,China) |
| |
| Abstract: | MA Shi-tang;DAI Guo-liang;CHENG Xiao-gui;ZHAO Wen-zhu;SUN Bing-ting;JU Wen-zheng;TAN Heng-shan(College of Food and Drug of Anhui Science and Technology University,Fengyang 233100,China;College of Pharmacy,Nanjing University of Traditional Chinese Medicine,Nanjing 210029,China;Department of Clinical Pharmacology,Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing 210029,China;Department of Clinical Pharmacology,General Hospital of Nanjing Military Area Command,Nanjing 210002,China) |
| |
| Keywords: | Compound Danshen Dripping Pill Systematical in-silico pharmacology Material basis for efficacy Platelet aggregation inhibition |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
