卡维地洛治疗2型糖尿病合并急性心肌梗死后心力衰竭的临床观察

目的 观察卡维地洛对2型糖尿病并发急性心肌梗死后心功能衰竭患者的疗效及安全性.方法 80例2型糖尿病并发急性心肌梗死后心功能衰竭患者随机分为常规治疗组(40例)和卡维地洛组(40例),卡维地洛组在常规治疗基础上加用卡维地洛.测定两组患者治疗前和治疗4周后临床心功能、校正的舒张末期容积指数(LVEDVI)、收缩末期容积指...

Effect of carvedilol on ventricular dysfunction in type 2 diabetes mellitus patients with acute myocardial infarction

Objective To observe the effect and safety of carvedilol on ventricular dysfunction in type 2 diabetes mellitus patients with acute myocardial infarction(AMI).Methods 80 patients were randomly divided into two groups:control group(n=40)received regular therapy,while carvedilol group(n=40)was treated with carvedilol on the basis of the regular treatment.All the patients were checked with index of left ventricular end systolic volume(LVESVI),left ventricular end diastolic volume(LVEDVI),left ventricular ejection fracture(LVEF),cardiac index(CI),levels of blood-lipids,concentration of fast plasma glucose(FPG),fast insulins(FINS),an-giotensinⅡ(AngⅡ),aldosterone(ALD),B-type natriuretic peptide(BNP),microalbum-inuria(UA)and cardiac function before and 4 weeks after treatment.Results After treatment,LVEF and cardiac function in carvedilol group were improved significantly compared with control group(P<0.01),the levels of AngⅡ,ALD and UA reduced markedly in the Carvedilol group(P<0.05 or P<0.01).There was no significant change in blood-lipids,BNP,concentration of FPG and FINS between the two groups.Conclusion Carvedilol may be a safe and effective drug in the treatment of patients with heart failure due to type 2 diabetes mellitus and acute myocardial infarction by improving the left ventricular function and remodeling,reducing UA level.It has no influence on blood glucose and lipid metabolism.