| 35例多发性硬化患者Th17细胞及相关细胞因子的检测 |
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| 引用本文： | 于周,吕志宇,李作孝. 35例多发性硬化患者Th17细胞及相关细胞因子的检测[J]. 重庆医学, 2011, 40(7). DOI: 10.3969/j.issn.1671-8348.2011.07.008 |
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| 作者姓名： | 于周 吕志宇 李作孝 |
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| 作者单位： | 四川省凉山彝族自治州第一人民医院神经内科,西昌,615000;泸州医学院附属医院神经内科,四川泸州,645000 |
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| 摘 要： | 目的 探讨多发性硬化(MS)患者外周血Th17细胞水平及相关细胞因子的意义.方法 采用流式细胞分析法检测35例MS患者(MS组)和20例健康者(对照组)外周血Th17细胞占CD4+T细胞比例,ELISA法检测外周血IL-17、IL-23水平.结果 MS组患者外周血Th17/CD4+T细胞比例[(1.94±0.32)%]显著高于对照组[(0.60±0.25)%],差异有统计学意义(P<0.01);MS组患者外周血IL-17、IL-23水平亦明显高于对照组[IL-17:MS组(69.01±19.29)ng/L、对照组(25.94±15.61)ng/L;IL-23:MS组(550.80±112.06)ng/L、对照组(158.78±33.19)ng/L,(P<0.01)].患者外周血IL-17水平与IL-23水平呈正相关(r=0.731,P<0.01).结论 MS患者外周血Th17/CD4+T细胞比例增加,相关细胞因子IL-17、IL-23水平升高,Th17细胞可能参与了MS的发生与发展.
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| 关 键 词： | 多发性硬化 白细胞介素 Th17细胞 |
Detection of Thl7 cells and related cytokines in 35 cases of multiple sclerosis |
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| Yu Zhou,Lv Zhiyu,Li Zuoxiao. Detection of Thl7 cells and related cytokines in 35 cases of multiple sclerosis[J]. Chongqing Medical Journal, 2011, 40(7). DOI: 10.3969/j.issn.1671-8348.2011.07.008 |
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| Authors: | Yu Zhou Lv Zhiyu Li Zuoxiao |
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| Affiliation: | Yu Zhou1,Lv Zhiyu2,Li Zuoxiao2(1 Department of Neurology,First Hospital of Liangshan,Xichang,Sichuan 615000,China,2.Department of Neurology,Affiliated Hospital of Luzhou Medical College,Luzhou,Sichuan 646000,China) |
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| Abstract: | Objective To investigate the levels of T help 17 cells(Th17) and related cytokines in the patients with multiple sclerosis(MS) and their significance to clinic.Methods IL-17 and IL-23 levels for multiple sclerosis patients and controls were evaluated by enzyme-linked immunoassay.The frequencies of Th17 in CD4+T cells were checked by flow cytometic analysis.Results The frequencies of Th17 in peripheral blood were found to be significantly higher in the patients with multiple sclerosis(P<0.01).Th17 type cytok... |
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| Keywords: | multiple sclerosis interleukin T help 17 cell |
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