糖化血红蛋白及糖化血清蛋白与糖尿病肾功能衰竭患者的血糖监测

糖化血红蛋白(Hb)A1c是血糖监测的苇要指标,反映检测前2～3个月的平均血糖水平.慢性肾功能衰竭(CRF)患者存在贫血、酸中毒、氧化应激、胰岛素抵抗、血液透析及促红细胞生成素(EPO)的应用等因素,对HbA1c的测定会造成影响.糖化血清蛋白(GSP)反映检测前2～3周的平均血糖水平,仅受血浆蛋白的影响,几乎不受血红蛋白和EPO治疗等以上因素的影响,且对短时间内的血糖变化更为敏感.将GSP作为糖尿病肾功能衰竭患者血糖监测指标可能比HbA1c更理想.

Effect of HbA1c and glycated serum protein for blood glucose monitor in diabetics with renal failure

Glycated hemoglobin Alc (HbAlc) is an important indicator of blood glucose monitor, which reflects the average blood glucose level of 2-3 months before the detection. In the patients with chronic renal failure (CRF), some factors can affect the level of HbA 1 c, such as anemia, acidosis, oxidative stress, in-sulin resistance, hemodialysis and application of erythropoietin (EPO). Glycated serum protein (GSP) re-flects the average blood glucose level of 2-3 weeks before the detection,which is only associated with the plas-ma proteins. It is almost not affected by hemoglobin, EPO treatment and other factors mentioned above and is more sensitive to the changes of blood glucose in a short period. GSP may be more appropriate for glucose mo-nitoring than HbAlc to diabetics with renal failure.