| 固相萃取GC-FID和GC-MS分析血浆中碱性药物 |
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| 引用本文： | 邱丰和,刘力,罗毅,刘峰,卢涌泉. 固相萃取GC-FID和GC-MS分析血浆中碱性药物[J]. 药学学报, 1996, 31(4): 296-299 |
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| 作者姓名： | 邱丰和 刘力 罗毅 刘峰 卢涌泉 |
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| 作者单位： | 军事医学科学院毒物药物研究所,北京 100850 *军事医学科学院仪器测试中心 |
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| 摘 要： | 报道了用X-5固相萃取分离、毛细管GC-FID和GC-MS定性定量分析人血浆中34种碱性药物的方法。在优化的提取条件下,大部分药物的最低检测浓度在0.5～2.0μg·ml-1之间,线性范围、定量精密度等满足临床中毒分析的要求。
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| 关 键 词： | 碱性药物 固相萃取 GC-FID GC-MS |
| 收稿时间： | 1995-06-30 |
SYSTEMATIC ANALYSIS OF BASIC DRUGS IN PLASMA USING X-5 SOLID-PHASE EXTRACTION GC-FID AND GC-MS |
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| FH Qiu,L Liu,Y Luo,F Liu,and YQ Lu. SYSTEMATIC ANALYSIS OF BASIC DRUGS IN PLASMA USING X-5 SOLID-PHASE EXTRACTION GC-FID AND GC-MS[J]. Acta pharmaceutica Sinica, 1996, 31(4): 296-299 |
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| Authors: | FH Qiu L Liu Y Luo F Liu and YQ Lu |
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| Abstract: | A systematic determination method for 34 hasic drugs in human plasma isdescribed. Drugs were extracted from plasma at pH 10 using X-5 resin as adsorbent,then identifiedand quantitated by capillary GC-FID and GC-MS.The detection limits for most drugs are in the rangeof0.5～2.0μg·ml-1.Precision and linearity of the method are satisfactory for clinical toxicologicalapplications. |
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| Keywords: | Solid-phase extraction GC-FID GC-MS Basic drugs |
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