帕瑞昔布钠预防硬膜外麻醉后寒战的临床观察

目的探讨预先静注帕瑞昔布钠对硬膜外麻醉后寒战的预防效果。方法选择硬膜外麻醉下行择期经尿道前列腺切除手术患者120例,随机均分为两组。硬膜外麻醉前30 min分别静注帕瑞昔布钠40 mg(P组)或等容量生理盐水(C组)。观察麻醉及手术过程中寒战的发生率、寒战的严重程度及寒战发生前后体温变化。结果 P组患者寒战发生率为5%,而C组为25%,P组明显低于C组(P<0.05)。结论预先静注帕瑞昔布钠40 mg可有效预防硬膜外麻醉后寒战的发生。

Clinical observation of parecoxib sodium for the prevention of shivering after epidural anesthesia

Objective To investigate the effect of parecoxib sodium treatment for the prevention of shivering after epidural anesthesia.Methods A total of 120 patients undergoing selective transurethral resection of the prostate(TURP) under epidural anesthesia were randomly divided into two groups with 60 cases each.Group P received perecoxib sodium 40 mg i.v.30 min before epidural anesthesia,and group C received equal volume of normal saline.The incidence rate and degree of shivering and the changes of body temperature before and after shivering were recorded during epidural anesthesia.Results The incidence rate of shivering in group P(5%) was significantly lower than that in group C(25%)(P<0.05).Conclusion Intravenous injection of parecoxib sodium 40 mg before anesthesia could effectively prevent the occurrence of shivering during epidural anesthesia.