| 肿瘤坏死因子对培养内皮细胞的损伤作用——循环内皮细胞形成机制初探 |
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| 引用本文： | 杨映波,王正国,朱佩芳. 肿瘤坏死因子对培养内皮细胞的损伤作用——循环内皮细胞形成机制初探[J]. 中国循环杂志, 1993, 0(6) |
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| 作者姓名： | 杨映波 王正国 朱佩芳 |
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| 作者单位： | 第三军医大学第三附属医院野战外科研究所创伤急救科(杨映波)，第三军医大学第三附属医院野战外科研究所第四研究室(王正国)，第三军医大学第三附属医院野战外科研究所第四研究室(朱佩芳) |
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| 摘 要： | 本文以原代培养的人脐静脉内皮细胞(HUVEC)为材料,研究了肿瘤坏死因子(TNF)对HUVEC的损伤作用及循环内皮细胞(CEC)的形成机制。实验结果表明,TNF能造成HUVEC大片脱落,并出现了与CEC极为相似的形态。同时,TNF明显破坏了纤溶酶原激活剂抑制物活性。结果表明,TNF的直接细胞毒作用可致HUVEC转变成CEC的细胞形态,TNF浓度增加可能是病理情况下CEC增多的重要原因。
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| 关 键 词： | 肿瘤坏死因子 人脐静脉内皮细胞 循环内皮细胞 纤溶酶原激活剂抑制物 |
EFFECTS OF TUMOR NECROSIS FACTOR ON CULTURED ENDOTHELIAL CELLS: A PRELIMINARY STUDY ON THE MECHANISM OF CIRCULATING ENDOTHELIAL CELL FORMATION |
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| Yang Ying-Bo,Wang Zheng-Guo,Zhu Pei-Fang. EFFECTS OF TUMOR NECROSIS FACTOR ON CULTURED ENDOTHELIAL CELLS: A PRELIMINARY STUDY ON THE MECHANISM OF CIRCULATING ENDOTHELIAL CELL FORMATION[J]. Chinese Circulation Journal, 1993, 0(6) |
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| Authors: | Yang Ying-Bo Wang Zheng-Guo Zhu Pei-Fang |
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| Affiliation: | Yang Ying-Bo,Wang Zheng-Guo,Zhu Pei-Fang. Daping Hospital,Third Military Medical College,Chongqing |
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| Abstract: | The effects of tumor necrosis factor (TNF) on cultured human umbilical vein endothelial cells (HUVEC) and the mechanism of circulating endothelial cell (CEC) formation had been studied. The results showed that TNF exfoliated HUVEC, produced CEC-like cells, and reduced the activity of plasminogen activator inhibitor (PAI) obviously. The results suggested that cytotoxicity of TNF can induce HUVEC to form CEC, which may be important in increasing CEC under certain pathological conditions. |
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| Keywords: | Tumor necrosis factor Human umbilical vein endothelial cells Circulating endothelial cells Plasminogen activator inhibitor |
| 本文献已被 CNKI 等数据库收录！ |
