| 1-(2-羟基-3-芳氧基丙基)-4-芳酰基哌嗪的合成 |
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| 引用本文： | 范云鸽,嵇耀武,黄志新,陈恒昌.1-(2-羟基-3-芳氧基丙基)-4-芳酰基哌嗪的合成[J].药学学报,1987,22(3):185-190. |
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| 作者姓名： | 范云鸽 嵇耀武 黄志新 陈恒昌 |
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| 作者单位： | 郑州大学化学系，郑州大学化学系，郑州大学化学系，郑州大学化学系 硕士研究生 |
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| 摘 要： | 根据拼合原理,设计并合成了19个1-(2-羟基-3-芳氧基丙基)-4-芳酰基哌嗪类化合物。对其中8个化合物I1～I8进行了药理试验,发现它们有明显的降压活性及α-受体阻滞活性。
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| 关 键 词： | 抗高血压 哌嗪衍生物 |
| 收稿时间： | 1986-03-05 |
SYNTHESES OF 1-(2-HYDROXY-3-ARYLOXYPROPYL)-4-AROYLPIPERAZINES |
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| FAN Yun-Ge,JI Yao-Wu,HUANG Zhi-Xin and CHEN Heng-Chang.SYNTHESES OF 1-(2-HYDROXY-3-ARYLOXYPROPYL)-4-AROYLPIPERAZINES[J].Acta Pharmaceutica Sinica,1987,22(3):185-190. |
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| Authors: | FAN Yun-Ge JI Yao-Wu HUANG Zhi-Xin and CHEN Heng-Chang |
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| Abstract: | Nineteen 1-(2-hydroxy-3-aryloxypropyl)-4-aroylpiperazines were designed according to synbiotic approach and then synthesized. Eight of them (from I1 to I8) were subjected to preliminary pharmacological assay. They were shown to have α-adrenergic blocking and hypotensive activities. |
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| Keywords: | Antihypertensive drug Piperazine derivatives |
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