胰周淋巴结转移瘤的多层CT灌注成像研究

目的 使用多层螺旋CT的体部灌注软件,测量和评价胰周淋巴结转移瘤与良性增生肿大淋巴结CT灌注值的差异和相关性.方法 采用Siemens SOMATOM Sensation Cardiac 64排螺旋CT体部灌注技术(0.4 s/周),5mm层厚,4层,120 kV,60mA;采用高压注射器注射非离子型对比剂40ml(300mg I/ml),流速4ml/s,延迟5s,数据采集40s.在工作站用Siemens Body Perfusion软件进行数据处理(去卷积算法),测量29例胰周淋巴结转移瘤和15例良性增生肿大淋巴结的血流量(BF),并进行统计学分析.结果 胰周淋巴结转移瘤BF平均值为(53.63±10.82)ml·min-1·100 ml-1,良性增生肿大淋巴结BF值为(29.78±7.52)ml·min-1·100 ml-1,差别有显著统计学意义(P<0.001).结论 MSCT灌注成像法对胰周淋巴结转移瘤的鉴别诊断具有临床应用价值.

Multiple spiral CT perfusion imaging in differential diagnosis of peri-pancreatic metastatic lymph nodes

Objective To measure and assess CT perfusion value for peri-pancreatic metastatic lymph node by using multiple spiral CT (MSCT) with body perfusion software package. Methods The MSCT perfusion imaging was performed for peri-pancreatic metastatic lymph nodes and muscle on a multi-section CT scanner (SOMATOM Sensation Cardiac 64). 4 x 5 mm collimation, 120 kV, 60mA. Contrast injection was done with 40 ml nonionic contrast agent (300 mg l/ml), at a flow rate of 4.0 ml/s, and 5 seconds delay, and data acquisition lasted for 40 seconds. The mean blood flow (BF) were measured and analyzed in patients with pathologically proven peri-pancreatic metastatic lymph nodes(n=29)and hyperplastic lymph nodes(n=15) on work station using body perfusion software (Siemens) with deconvolution method. Results The mean BF in peri-pancreatic metastatic lymph nodes were (53.63±18.82) ml·min-1·100 ml-1, in hyperplastic lymph nodes were 29.78±7.52 ml·min-1·100 ml-1, the difference was significant (P<0.001). Conclusions Perfusion imaging of MSCT was useful in differentiation between peri-pancreatic metastatic lymph nodes and hyperplastic lymph nodes.