Tissue engineering in dentistry |
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Authors: | Ensanya Ali Abou Neel Wojciech Chrzanowski Vehid M Salih Hae-Won Kim Jonathan C Knowles |
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Institution: | 1. Division of Biomaterials, Operative and Aesthetic Department Biomaterials Division, King Abdulaziz University, Jeddah, Saudi Arabia;2. Biomaterials Department, Faculty of Dentistry, Tanta University, Tanta, Egypt;3. UCL Eastman Dental Institute, Biomaterials & Tissue Engineering, 256 Gray''s Inn Road, London WC1X 8LD, UK;4. The University of Sydney, The Faculty of Pharmacy, NSW 2006 Sydney, Australia;5. Department of Nanobiomedical Science & BK21 Plus NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 330-714, Republic of Korea;6. Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 330-714, Republic of Korea;g Department of Biomaterials Science, College of Dentistry, Dankook, University, Cheonan 330-714, Republic of Korea;h Plymouth University Peninsula School of Medicine & Dentistry, Drake''s Circus, Plymouth PL4 8AA, Devon, UK |
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Abstract: | Objectivesof this review is to inform practitioners with the most updated information on tissue engineering and its potential applications in dentistry.DataThe authors used “PUBMED” to find relevant literature written in English and published from the beginning of tissue engineering until today. A combination of keywords was used as the search terms e.g., “tissue engineering”, “approaches”, “strategies” “dentistry”, “dental stem cells”, “dentino-pulp complex”, “guided tissue regeneration”, “whole tooth”, “TMJ”, “condyle”, “salivary glands”, and “oral mucosa”.SourcesAbstracts and full text articles were used to identify causes of craniofacial tissue loss, different approaches for craniofacial reconstructions, how the tissue engineering emerges, different strategies of tissue engineering, biomaterials employed for this purpose, the major attempts to engineer different dental structures, finally challenges and future of tissue engineering in dentistry.Study selectionOnly those articles that dealt with the tissue engineering in dentistry were selected.ConclusionsThere have been a recent surge in guided tissue engineering methods to manage periodontal diseases beyond the traditional approaches. However, the predictable reconstruction of the innate organisation and function of whole teeth as well as their periodontal structures remains challenging. Despite some limited progress and minor successes, there remain distinct and important challenges in the development of reproducible and clinically safe approaches for oral tissue repair and regeneration. Clearly, there is a convincing body of evidence which confirms the need for this type of treatment, and public health data worldwide indicates a more than adequate patient resource. The future of these therapies involving more biological approaches and the use of dental tissue stem cells is promising and advancing. Also there may be a significant interest of their application and wider potential to treat disorders beyond the craniofacial region.Clinical SignificanceConsidering the interests of the patients who could possibly be helped by applying stem cell-based therapies should be carefully assessed against current ethical concerns regarding the moral status of the early embryo. |
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Keywords: | Tissue engineering strategies Biomimetic scaffolds Dentine-pulp complex Bioengineered teeth |
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