地氯雷他定的分子印迹聚合物的制备及其吸附性研究 |
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引用本文: | 蒲家志,安立群.地氯雷他定的分子印迹聚合物的制备及其吸附性研究[J].数理医药学杂志,2009,22(4):437-440. |
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作者姓名: | 蒲家志 安立群 |
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作者单位: | 遵义医学院药学系,遵义563003 |
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摘 要: | 目的:以地氯雷他定为模板分子,分别用甲基丙烯酸(MAA)、丙烯酰胺(AM)和两者(1:1)的混合物为功能单体制备了相应的聚合物。方法:将模板分子、功能单体、交联剂,按1:4:20比例制备相应的分子印迹聚合物,再将制得的棒状聚合物经过研磨、过筛后,采用平衡结合方法评价了该分子印迹聚合物的吸附结合特性。结果:研究表明,采用MAA为功能单体,以乙酸乙酯做溶剂合成的地氯雷他定MIP对模板分子的结合性最佳。结论:地氯雷他定MIP作为固相萃取填料,在临床体液样品中对地氯雷他定的富集和检测有应用前景。
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关 键 词: | 分子印迹 地氯雷他定 识别选择性 |
Synthesis and Characterization of Molecularly Imprinted Polymer of Desloratadine |
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Abstract: | Objective: To select a suitable functional monomer to synthesize molecular.Methods: Molecular imprinted polymers were synthesiged with MAA,AAM and MAA-AAM(1:1) as functional monomers in different solution,using UV as a detechion.Results: The polymer taking MAA as functional monomer and acetic ether as solvent obtained higher selectivity for desloratadine.Conclusion: Molecular imprinted polymers exhibit clinical utility for enrichment and determination of trace desloratadine. |
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Keywords: | molecular imprinted polymers desloratadine identifying selectivity of identification |
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