线粒体DNA与骨髓增生异常综合征

线粒体是生物氧化和能量转换的主要场所。线粒体DNA编码线粒体内的呼吸链复合物．mtDNA突变可引起多种人类疾病。在骨髓增生异常综合征（MDS）中发现的mtDNA突变可能从铁代谢障碍、基因不稳定以及造血干细胞凋亡等方面参与MDS的发病过程。本文就线粒体DNA的结构特点、线粒体DNA突变和线粒体突变在MDS发病中的可能机制作一综述。

Relationship between Mitochondrial DNA and Myelodysplastic Syndromes——Review

Mitochondria is the main place of biological oxidation and energy transform. Mitochondrial DNA encodes the complex of respiratory chain in mitochondria and its mutation can cause a series of human disease. Mitochondrial DNA mutation which observed in myelodysplastic syndrome (MDS) patients cause the MDS by the mechanism of iron metabolism disorder, gene instability and hemopoietic progenitor cell apoptosis. In this review the characteristics of mitochondrial DNA structure, the mitochondrial DNA mutation and the possible mechanism of mitochondrial DNA mutation in pathogenesis of MDS were summarized.