下肢骨折患者术后深静脉血栓与D-二聚体、超敏C-反应蛋白的关系探讨

目的探讨下肢骨折患者术后深静脉血栓与D-二聚体和超敏C-反应蛋白(hs-CRP)的关系。方法同时测定49例深静脉血栓(DVT)患者(实验组)和52例未发生深静脉血栓患者(对照组)血浆D-二聚体、PT、APTT以及血清hs-CRP的水平。结果术后24 h和48 h实验组的hs-CRP、D-二聚体均高于对照组(P<0.05);实验组在术后48 h的hs-CRP、D-二聚体浓度高于24 h时的测定值(P<0.05)。对照组在术后24 h和48 h的hs-CRP、D-二聚体、PT和APTT测定结果差异无统计学意义(P>0.05)。结论联合检测D-二聚体和hs-CRP可用于下肢骨折患者术后深静脉血栓的早期诊断。

Discussion on the Relationship Between Postoperative Deep Vein Thrombosis and D-dimer as well as High Sensitivity C-reactive Protein in Patients with Lower Limb Fractures

Objective To discuss the relationship between postoperative deep vein thrombosis（DVT）in lower limb fracture patients with D-dimer and high sensitivity C-reactive protein （hs-CRP）. Method Plasma D-dimer, pT, APTT and serum hs-CRP levels in 49 DVT patients（experimental group）and 52 patients without DVT（control group）were simultaneously determinated. Results In 24 h and 48 h after operation hs-CRP and D-direct in experimental group were higher than that in control group（P〈0.05）; In experimental group, hs-CRP and D-dimer concentrations in 48h were higher than that measured in 24 h（P〈0.05）, hs-CRP, D-dimer, PT and APTT showed no significant difference in the control group between 24 h and 48 h after operation （P〉0.05）. Conclusion Combined detection of D-dimer and hs-CRP can be used for the early diagnosis of postoperative deep vein thrombosis in lower limb fracture patients.