H型高血压对急性冠脉综合征的影响

目的探讨H型高血压对急性冠脉综合征(ACS)的影响。方法 2011年1月—2012年1月收治的130例高血压合并冠心病的患者为研究对象,按照高血压同型半胱氨酸(Hcy)水平的不同,将其分为H型高血压组(Hcy≥10μmol/L)69例和单纯性高血压组(Hcy<10μmol/L)61例,比较两组患者中ACS患者及非ACS患者的三酰甘油(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、Hcy、高敏C-反应蛋白(hs-CRP)。结果 H型高血压组中的ACS患者的Hcy、hs-CRP水平显著高于非ACS患者,差异有统计学意义(P<0.05),其他观察指标差异无统计学意义(P>0.05)。单纯性高血压组中,ACS患者的Hcy、hs-CRP水平亦显著高于非ACS患者(P<0.05),其他观察指标差异无统计学意义(P>0.05)。H型高血压组ACS患者的比例显著高于单纯性高血压组(P<0.05)。结论 H型高血压与ACS密切相关,与炎症反应亦密切相关,能降低Hcy水平,可有效降低急性心血管事件的发生率。

Effect of H Type Hypertension and Acute Coronary Syndrome

Objective To investigate the association between H-hypertension and Acute Coronary Syndrome(ACS).Methods 130 patients with hypertension combined with coronary heart diseases admitted and treated in our hospital from January 2011 to January 2012.According to different levels of hypertension homocysteine(Hcy),they were divided into the H-hypertension group(Hcy≥10 μmol/L) with 69 patients and the simple hypertension group(Hcy<10 μmol/L)with 61 patients.Hcy,triglyceride(TG),cholesterol(TC),low density lipoprotein(LDL-C) and high density lipoprotein(HDL-C),hypersensitive C reactive protein(hs-CRP) of patients with ACS and patients without ACS in the H-hypertension group were compared.Results The Hcy and hs-CRP level of the two group patients with ACS was both significantly higher than that of those without ACS(P<0.05),and the other observation indexes had no significant differences(P>0.05).The proportion of patients with ACS in the H-hypertension group was significantly higher than that of the simple hypertension group(P<0.05).Conclusion H-hypertension is closely related to ACS and inflammatory reaction.If Hcy levels can be effectively reduced,the incidence of acute cardiovascular events may be decreased.