| 特拉唑嗪单芯渗透泵片研制及其控制释放的因素 |
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| 引用本文： | 葛乐乐,范辉.特拉唑嗪单芯渗透泵片研制及其控制释放的因素[J].中国医院药学杂志,2007,27(6):740-743. |
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| 作者姓名： | 葛乐乐 范辉 |
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| 作者单位： | 浙江大学医学院附属邵逸夫医院,浙江,杭州,310016 |
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| 摘 要： | 目的：研制难溶性药物特拉唑嗪的单芯渗透泵。方法：片芯中加入亲水性高分子，用乙基纤维素溶液包衣制备单尊渗透泵，并研究片芯处方、释药孔径等因素对释药行为的影响。结果：在0．80-1．15mm范围内，孔径对制备的渗透泵片释药行为没有影响，且自制渗透泵片在0～24h释放速度平稳，与胃肠道环境pH值和溶出仪转速无关。结论：制备的单芯渗透泵
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| 关 键 词： | 特拉唑嗪 控制释放 单芯渗透泵 |
| 文章编号： | 1001-5213（2007）06-0740-04 |
| 修稿时间： | 2006-09-05 |
Preparation of terazosin monolithic osmotic pump tablets and factors of controlled release |
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| GE Le-le,FAN Hui.Preparation of terazosin monolithic osmotic pump tablets and factors of controlled release[J].Chinese Journal of Hospital Pharmacy,2007,27(6):740-743. |
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| Authors: | GE Le-le FAN Hui |
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| Institution: | Affiliated Sir Run Run Shaw Hospital, Zhejiang University Medical College, Zhejiang Hangzhou 310016, China |
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| Abstract: | OBJECTIVE To prepare terazosin monolithic osmotic pump tablets. METHODS A hydrophilic high molecular weight Compound was added into the core tablets and then the monolithic osmotic pump tablets were prepared by coating with ethylcellulose. The effects of the formulation of core tablets and orifice size on drug release were observed. RESULTS The orifice size of tablets in the range of 0. 80-1.15 mm scarcely affected the drug release. The osmotic pump tablets could release drug constantly for 24 h. It was seldom affected by the gastrointestinal pH value and the rotation speed of the dissolution apparatus. CONCLUSION The terazosin monolithic osmotic pump tablets had stable drug release. |
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| Keywords: | terazosin control release monolithic osmotic pump tablets |
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