| Abstract: | A graft versus host reaction (GVHR) was induced in F1(CBA×C57BL/6) female hybrids by intravenous injection of a suspension of lymphocytes from the spleen and lymph glands from C57BL/6 females. Pregnancy, which developed as a result of crossing the experimental females with syngeneic males 1–10, 10–20, 30–40, and over 40 days after injection of the lymphocytes, aggravated the transplantation sickness due to the GVHR. On the other hand, the GVHR under these conditions reduced the percentage of animals that became pregnant and disturbed the reproductive function of the experimental mice (stillbirth, death of the pregnant females, abortion). An exacerbation of the GVHR was observed in some of the experimental animals after giving birth. The rate of survival of the progeny was lowered.Department of Microbiology, Smolensk Medical Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR N. N. Zhukov-Verezhnikov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 80, No. 9, pp. 68–71, September, 1975. |
