Risk factors for endometriosis in the rhesus monkey (Macaca mulatta): a case-control study |
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| Authors: | Hadfield, RM Yudkin, PL Coe, CL Schefler, J Uno, H Barlow, DH Kemnitz, JW Kennedy, SH |
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| Affiliation: | 0 Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK 3 Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, WI, USA 1 Department of Public Health and Primary Care, University of Oxford, Radcliffe Infirmary, Oxford, UK 2 Harlow Primate Laboratory, Department of Psychology, University of Wisconsin, Madison, WI, USA z Corresponding author |
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| Abstract: | ![]()
The autopsy records between 1980 and 1995 of 399 female rhesusmonkeys (Macaca mulatta) at the Wisconsin Regional Primate ResearchCenter were examined. Spontaneous endometriosis was found in81 (20%) of the animals. The mean (±SD) ages at deathfor animals with and without endometriosis were 20.7±5.5(range 10-35) and 13.4±7.7 (range 4-37) years respectively.Many of the animals had been exposed to experimental procedures,including laparoscopies, hysterotomies and oestradiol implants,and these were examined as possible risk factors for endometriosis.Of the 81 affected animals, 62 were matched to unaffected controlsfor age at death (to within 1 year) and year of death (to within2 years) and the effect of various factors on the developmentof endometriosis was determined using conditional logistic regression.Exposure to three or more oestradiol implants or one or morehysterotomies were both significant risk factors, with estimatedrelative risks of 9.7 (95% confidence interval 2.5-37.2) and5.8 (95% confidence interval 1.6-20.2) respectively. Animalsthat had been exposed to one or more laparoscopies showed noincreased risk for developing endometriosis. These findingsprovide insight into the aetiology of the disease in women. |
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| Keywords: | caesarean section/endometriosis/oestradiol/rhesusmonkey/risk factors |
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