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| 黄芪总皂苷和三七总皂苷配伍对大鼠局灶性脑缺血的影响 | |
| 引用本文： | 任周新,李丽,李君,罗永明. 黄芪总皂苷和三七总皂苷配伍对大鼠局灶性脑缺血的影响[J]. 中国实验方剂学杂志, 2006, 12(12): 56-58 |
| 作者姓名： | 任周新 李丽 李君 罗永明 |
| 作者单位： | 1. 北京中医药大学中药学院,北京,100102;河南中医学院,河南,郑州,450008 2. 河南中医药研究院附属医院,河南,郑州,450004 3. 江西中医学院药学系,江西,南昌,330004 |
| 摘 要： | 目的:运用线栓制作脑缺血再灌注大鼠模型,观察黄芪总皂苷和三七总皂苷配伍对脑梗塞百分率的影响。方法及结果:应用二因素五水平均匀设计方法,观察到黄芪总皂苷16 mg/kg和三七总皂苷40 mg/kg配伍时,抗脑梗死形成作用最佳,2×2析因设计试验发现该剂量下两药配伍对于大鼠脑梗死有相加的保护作用。结论:黄芪总皂苷和三七总皂苷配伍具有协同的抗脑梗死作用。 |
| 关 键 词： | 黄芪总皂苷 三七总皂苷 抗脑缺血 协同作用 |
| 文章编号： | 1005-9903(2006)12-0056-03 |
| 收稿时间： | 2006-05-12 |
| 修稿时间： | 2006-05-12 |
Effect of Compatibility on Anti-ischemia of Rats with Astragalasides and Total Saponins of Pnanx notoginseng |
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| REN Zhou-xin,LI Li,LI Jun,LUO Yong-ming. Effect of Compatibility on Anti-ischemia of Rats with Astragalasides and Total Saponins of Pnanx notoginseng[J]. China Journal of Experimental Traditional Medical Formulae, 2006, 12(12): 56-58 | |
| Authors: | REN Zhou-xin LI Li LI Jun LUO Yong-ming |
| Affiliation: | REN Zhou-xin~ |
| Abstract: | Objective:To investigate the interactions between astragalosides(AS) and total saponins of Pnanx notoginseng(SPN) with various dosage.Methods:The model of focal cerebral ischemia by suture method in rats was used( ) in the study.The results were analysed with two statistics.Results:AS and SPN showed antiischemia effect.The compatible application of AS with dose of 16 mg/kg and SPN with dose of 40 mg/kg indicated more significant anti-ischemia action.Conclusion: The compatible application of AS and SPN related in a synergistic effect of anti-ischemia. |
| Keywords: | Astragalosides Saponins of Pnanx notoginseng Anti-ischemia Synergistic effect |
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