烧伤患者静脉留置针检出金黄色葡萄球菌及耐药性分析

目的分析烧伤患者静脉留置针金黄色葡萄球菌检出率及耐药谱,为临床治疗及合理使用抗菌药物提供参考。方法收集175例烧伤患者静脉留置针标本,经培养分离后,采用法国生物梅里埃公司的细菌鉴定、药敏条进行鉴定及药敏分析。结果烧伤患者静脉留置针致病菌以金黄色葡萄球菌为主,占60.3%;所有菌株均为耐甲氧西林金黄色葡萄球菌(MRSA),对青霉素、苯唑西林、庆大霉素的耐药率为100.0%,对克林霉素、四环素、利福平等的耐药率均>50.0%,对米诺环素、替考拉宁耐药率为2.3%,未发现万古霉素、夫西地酸、喹奴普汀/达福普汀耐药株。结论金黄色葡萄球菌为烧伤患者静脉留置针感染的主要致病菌,且耐药性严重,及时对烧伤患者静脉留置针进行细菌培养及药敏检测,对于临床合理应用抗菌药物、减少耐药菌株产生有重要意义。

Isolation of Staphylococcus aureus from Detention Needles of Burn Patients and Analysis of Its Antibiotic Resistance

OBJECTIVE To study the detectable rate and the antibiotic resistance of Staphylococcus aureus from detention needles of burn patients,and provide instruction of clinic reasonably using antibiotics and clinical treatment.METHODS Totally 175 specimens detention needles of from burn patients were collected to isolate pathogenic organisms.Identification of bacterial strains and susceptibility tests were performed by ATB system.RESULTS S.aureus isolated from the detention needles of burn patients was the predominant pathogen,accounted for 60.3%,and all of them were MRSA.Among these flora,all were resistant to penicillins,oxacillin and gentamicin and more than 50.0% were resistant to lincomycin,tetracyc1ine,rifampicin and so on,2.3% were resistant to minocycline and teicoplanin,and none was resistant to vancomycin, fusidic acid,and quinupristin-dalfopristin.CONCLUSIONS S.aureus isolated from the detention needles of burn patients is the predominant pathogen, which is resistant to many antibiotics.So we should identify the bacterial strains and give susceptibility tests of detention needles from burn patients promptly,in order to provide best instruction on clinic reasonably using antibiotics and slow the development of the resistant bacterial flora.