希明婷片治疗女性围绝经期综合征的临床研究

目的〓〖HTK〗探讨希明婷片治疗围绝经期综合征的有效性和安全性。 〖HTW〗方法〓〖HTK〗采用随机、双盲、平行对照研究方法，将60例女性围绝经期综合征患者随机分为试验组（希明婷，50mg/片，每次1片，每日3次，连服4周）和对照组（倍美力，0.3mg/片，每次1片，每日1次，连服4周），每组30例。观察治疗前后潮热、烦躁易怒、失眠、腰膝酸软等围绝经期综合征相关症状评分的改变，以及血尿常规、肝肾功能、激素水平的变化。〖HTW〗结果〓〖HTK〗治疗后，改善潮热汗出和眩晕的症状试验组和对照组疗效相当（P＞0.05）；改善神经质、失眠、虚弱、心悸的症状，试验组疗效优于对照组（Ｐ＜0.05）；改善关节痛、头痛、蚁走感等症状，试验组疗效次于对照组（P＜0.05）。治疗前后血常规、肝、肾功能、血E2、FSH及子宫内膜厚度的改变，两组之间差异无统计学意义（P＞0.05）。治疗期间两组均未发生异常的阴道流血情况。〖HTW〗结论〓〖HTK〗希明婷片治疗围绝经期综合征安全且有效。

Ximingting tablets in the treatment of women with climacteric syndrome

Objective To observe the efficacy and safety of Ximingting tablets in the treatment of women with climacteric syndrome.Methods This was a randomized,double-blind and controlled trial.Sixty patients with climacteric symptoms were randomly assigned into two parallel groups: the investigated group and the Beimeili-controlled group.The climacteric symptoms,such as flushes,sweating,and irritation were studied before and after treatment.Changes of blood routine, urine routine,liver and kidney function and hormones(E2,FSH) were also assessed.Result After treatment,hot flushes,sweating and vertigo in the two groups showed no significant differences(P>0.05),however,irritation and insomnia,depression,weakness,heart-throb in the investigated group were superior to those in the Beimeili-controlled group(P<0.05),while arthralgia,headache and formication in the investigated group were inferior to those in the Beimeili-controlled group(P<0.05).Blood routine,urine routine,liver and kidney function and hormones(E2,FSH) in the two groups had no significant differences(P>0.05).Conclusion Ximingting tablets are efficacious and safe for the treatment of women with climacteric syndrome.