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| 老年大鼠耳蜗螺旋神经节Caspase-3、Calretinin的表达 | |
| 引用本文： | 王永生,董雪蕾. 老年大鼠耳蜗螺旋神经节Caspase-3、Calretinin的表达[J]. 中国现代医生, 2012, 50(14): 13-14 |
| 作者姓名： | 王永生 董雪蕾 |
| 作者单位： | 1. 深圳市第三人民医院耳鼻咽喉科,广东深圳,518112 2. 郑州大学第三附属医院耳鼻咽喉科,河南郑州,450052 |
| 摘 要： | 目的探讨老年性聋的发病机制。方法建立D-半乳糖衰老大鼠模型，获取老年大鼠耳蜗标本并以正常青年大鼠作对照，用免疫组化SP法检测老年大鼠和青年大鼠耳蜗螺旋神经节Caspase-3，Calretinin的表达。结果老年大鼠耳蜗螺旋神经节Caspase-3，Calretinin的积分光密度明显高于对照组（P〈0．05）。结论老年大鼠耳蜗螺旋神经节Caspase-3、Calretinin含量升高。 |
| 关 键 词： | 老年性聋 耳蜗 螺旋神经节 caspase-3 Calretinin |
Expression of Caspase-3, Calretinin in spiral ganglion of aged rats |
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| WANG Yongsheng , DONG Xuelei. Expression of Caspase-3, Calretinin in spiral ganglion of aged rats[J]. , 2012, 50(14): 13-14 | |
| Authors: | WANG Yongsheng DONG Xuelei |
| Affiliation: | 1.Department of ENT,Shenzhen Third People’s Hospital in Guangdong Province,Shenzhen 518112,China;2.Department of ENT,The Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China |
| Abstract: | Objective To explore injury cochlea mechanism of presbycusis.Methods Establishment of D-galactose aging rats model to obtain the cochlear specimens of aged rats.As a control in normal young rats,using immunohistochemical SP staining methods detected the expression of Caspase-3,Calretinin in the cochlear spiral ganglion of aged rats and young rats.Results The integral optical density of Caspase-3,Calretinin in the spiral ganglion of aged rats was significantly higher than the control group(P < 0.05).Conclusion The content of Caspase-3,Calretinin is increased in the spiral ganglion of aged rats. |
| Keywords: | Presbycusis cochlear Spiral ganglion Caspase-3 Calretinin |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |