脑梗死急性期TNF-α和IL-6水平变化及临床意义

目的探讨TNF-α和IL-6在脑梗死发病机制中的作用及临床意义。方法ELISA法动态检测56例急性脑梗死患者的血清TNF—α和IL-6水平变化并作NIHSS和Barthel指数评分，另设40例年龄、性别与体重指数（BMI）相匹配的健康体检者作为对照。结果急性脑梗死组入院时（24h内）血清IL-6、TNF-α浓度显著增高，与对照组相比，差异有统计学意义（P〈0．01）；第3天达峰值水平，然后逐渐下降，至第28天时仍高于对照组（P〈0．01）；脑梗死患者入院第1天、第3天、第7天血清TNF-α、IL-6水平与同期NIHSS评分呈正相关，与Barthel指数呈负相关。结论急性脑梗死患者血清TNF-α和IL-6浓度变化与病情和预后密切相关；联合检测TNF-α和IL-6可评估急性脑梗死患者的病情及预后。

Change and its clinical significance of TNF-α and IL-6 in patients with acute ischemic stroke

Objective To treat the change and clinical significance of Tumor necrosis factor-α(TNF-α) and Interleukin 6(IL-6) in patients with acute ischemic stroke through dynamically assaying the serum concentration of TNF-α and IL-6.Methods Fifty-six patients with acute ischemic stroke(study group) were selected.The serum concentration of TNF-α and IL-6 were dynamically assayed,and the NIHSS and BI score were evaluated.In addition,40 healthy age,gender,body mass index(BMI)-matched healthy subjects(control group) were evaluated.Results The serum concentration of TNF-α and IL-6 on admission in study group were higher than that in control group(P < 0.01).They got to the peak on the third day, then decreased gradually.Pearson correlation analysis showed that the serum concentration of TNF-α and IL-6 in patients on admission,third day and seventh day were positively concerned with NIHSS scores(all P < 0.05),whereas negatively concerned with BI(all P < 0.05).Conclusion The serum concentration of TNF-α and IL-6 is associated with pathogenetic condition and outcome.Assaying the serum concentration of TNF-α combined IL-6 should be of importance as referred indexes.