Suppression of antibody formation by bone marrow T cells activated by histocompatibility antigens

The suppressive action of bone marrow T cells activated by histocompatibility antigens on antibody formation was studied. The bone marrow of CBA mice was shown to contain thymus-dependent lymphocytes which, on hyperactivation by repeated transplantation into F₁ recipients, have a suppressive action on the development of the cooperative immune response to sheep's red cells. Preliminary treatment of the bone marrow cells with antithymocytic globulin and complement abolished the suppressive effect.Institute of Biophysics, Ministry of Health of the USSR, Moscow. (Presented by Academician of the Academy of Sciences of the USSR, P. D. Gorizontov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 83, No. 3, pp. 300–302, March, 1977.