纤维蛋白原与冠心病相关分析

目的探讨纤维蛋白原（Fg）与冠心病（CHD）类型及冠状动脉病变程度的相关性。方法将经冠状动脉造影的195例患者分为冠心病组（158例）与健康对照组（37例）,其中冠心病组又分为急性心肌梗死（AMI）组50例,不稳定型心绞痛（UAP）组60例,稳定型心绞痛（SAP）组48例。再将冠心病组按冠状动脉造影结果分为单支54例,双支55例,和三支病变组49例。应用Clauss凝固法测定195例全部入选者的Fg水平。比较各CHD类型及冠脉病变程度组间血浆Fg水平差异。结果Fg水平在正常对照组与SAP、UAP、AMI中差异有统计学意义,并随冠心病的严重程度呈上升趋势,Fg水平（g/L）分别为2.47±0.30、2.53±0.49、3.02±0.54和3.26±0.64,4组间比较,差异有统计学意义,P〈0.05。CHD患者Fg水平（g/L）在冠状动脉病变不同支数中分别为2.66±0.54、2.98±0.54和3.22±0.69,3组间比较,单支与其他支病变差异有统计学意义,P〈0.05,双支与多支病变间比较差异无统计学意义。结论CHD患者血浆Fg水平与冠心病的发展方向有关,随着斑块的不稳定呈现上升趋势,且与冠脉病变的程度呈正相关。

The relativity of fibrinogen and coronary heart disease

Objective To investigate the correlation of degree and type of coronary artery pathologic change with fibrinogen in CHD patients. Methods 158 CHD patients and 37 normal control patients were recruited for this study. Plasma Fg was examined in all subjects by using Clauss method. Cases with ~〉50% stenosis in at least one of the three coronary vessels were angiographically defined as having CHD.CHD group was divided into three groups by the results of the CAG. Results The plasma Fg levels（g/L） of control group,SAP,UAP,AMI were 2.47± 0.30,2.53±0.49,3.02 ±0.54,3.26±0.64 respectively. The deference among the three groups was significant on the plasma Fg levels.Plasma Fg levels was positively correlated with coronary artery gensini. There was have correlation between plasma Fg levels and the number of stenosised conronary vessels in CHD patients.The plasma Fg levels（g/L） of one vessels,double vessels,three vessels were 2.66±0.54,2.98±0.54,3.22±0.69. Conclusion There was higher plasma Fg level in CHD patients.Plasma Fg levels was positively correlated with CAG in CHD patients. Plasma Fg levels maybe reflect the degree of coronary pathologic change in CHD patients.There may have important role for treatment of degreasing plasma Fg on retarding the development of coronary artery pathologic change in CHD patients.