Prostate-specific antigen,prostate volume and transition zone volume in Japanese patients with histologically proven benign prostatic hyperplasia

The relationship among age, prostate-specific antigen (PSA) level andprostate volume in Japanese patients with lower urinary tract symptoms(LUTS) and histologically proven benign prostatic hyperplasia (BPH) wasexamined in order to assess the utility of PSA as a predictor of prostatevolume. Two hundred eighteen patients with LUTS were confirmed to haveBPH by histological examination for the reason of elevated PSA and/orabnormal digital rectal examination finding. Correlation among PSA,prostate volume and transition zone volume were analyzed in patientsclassified into age-stratified groups. Prostate volume increased with age.Mean serum PSA increased with age, and the correlation of PSA and prostatevolume was determined to be statistically significant in each cohort of age.A correlation coefficient ranged from 0.315 to 0.439. In patients with LUTSand clinical BPH, serum PSA increased with age and was related to prostatevolume. PSA might be useful for therapeutic decision making for patientswith symptomatic BPH.