GC测定镇江巴布膏中冰片、薄荷脑、樟脑和水杨酸甲酯的含量

目的 建立同时测定镇江巴布膏中冰片、薄荷脑、樟脑和水杨酸甲酯含量的方法.方法 采用GC法,以萘为内标物,色谱柱为HP-INNOMAX毛细管柱(30 m×0.32 mm,1.0 μm),进样口温度为230 ℃,FID检测器温度为250 ℃;采用程序升温,起始温度为90℃,保持7 min,以5 ℃·min-1的速率升至14...

Simultaneous Determination of Borneol,Menthol,Camphor,and Methylsalicylate in Zhenjiang Babu Plaster by GC

Objective To establish GC method for simultaneous determination of borneol,menthol,camphor and methylsalicylate contents in Zhenjiang Babu plaster.Methods The internal standard was Naphthalene.HP-INNOMAX quartz capillary column（30 m×0.32 mm,1.0μm） and FID were used.The injector temperature was 230℃ and the detector temperature was 250 ℃.Column temperature raised by programming with beginning temperature at 90℃,maintaining for 7 min,then increased the temperature to 140℃ at the rate of 5℃·min-1,maintaining for 13 min.Results The linear ranges of borneol,isoborneol,menthol,camphor and methylsalicylate were： 0.033 0～0.329 8 mg/mL（r=0.999 0）,0.015 9～0.158 8 mg/mL（r=0.999 0）,0.050 7～0.507 1 mg/mL（r=0.999 1）,0.060 0～0.599 8 mg/mL（r=0.999 2）,0.247 0～2.470 4 mg/mL（r=0.999 0）,The average recoveries were 99.12%、99.96%、100.53%、100.94% and 104.58%,and all RSD were less than 5%（n=6）.Conclusion This method is sensitive,accurate and reproducible.It can be used to control the quality of Zhenjiang Babu plaster.