| 郁星菖志汤对脑卒中后抑郁大鼠脑组织NE、5-HT水平的影响 |
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| 引用本文： | 洪杰斐,李君良,张兆强,揭新明,钟志国,罗磊玲.郁星菖志汤对脑卒中后抑郁大鼠脑组织NE、5-HT水平的影响[J].辽宁中医药大学学报,2012(2):9-10. |
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| 作者姓名： | 洪杰斐 李君良 张兆强 揭新明 钟志国 罗磊玲 |
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| 作者单位： | 广东医学院 |
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| 基金项目： | 广东省中医药局资助项目(2008170) |
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| 摘 要： | 目的:探讨中药郁星菖志汤对脑卒中后抑郁的作用机制。方法:建立脑卒中后抑郁大鼠模型,用酶联免疫法检测郁星菖志汤、氟西汀对受试大鼠脑组织NE、5-HT含量的影响。结果:模型组与空白对照组比较,NE、5-HT水平显著降低;郁星菖志汤组、氟西汀组与模型组比较,均有显著性差异(P<0.005);郁星菖志汤组与氟西汀组比较,无显著性差异(P>0.005)。结论:郁星菖志汤能显著提高脑卒中后抑郁大鼠脑组织NE、5-HT水平。
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| 关 键 词： | 脑卒中后抑郁 郁星菖志汤 NE 5-HT |
Influence of Yuxing Changzhi Decoction on Levels of NE and 5-HT in Brain Tissue of Rats With Post-Stroke Depression |
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| HONG Jie-fei,LI Jun-liang,ZHANG Zhao-qiang,JIE Xin-ming,ZHONG Zhi-guo,LUO Lei-ling.Influence of Yuxing Changzhi Decoction on Levels of NE and 5-HT in Brain Tissue of Rats With Post-Stroke Depression[J].Journal of Liaoning University of Traditional Chinese Medicine,2012(2):9-10. |
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| Authors: | HONG Jie-fei LI Jun-liang ZHANG Zhao-qiang JIE Xin-ming ZHONG Zhi-guo LUO Lei-ling |
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| Institution: | (Guangdong Medical College,Zhanjiang 524001,Guangdong,China) |
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| Abstract: | Objective:To explore the mechanism of Yuxing Changzhi decoction on treating post-stroke depression.Method:To establish post-stroke depression model of rat,using ELISA to detect the influence of Yuxing Changzhi decoction on NE and 5-HT contents in brain tissue.Results:Compared to control group,the NE and 5-HT levels in brain tissue is lower significantly in the model group;Yuxing Changzhi decoction group and fluoxetine group are different significantly than the control group(P<0.005);Yuxing Changzhi decoction group is not different significantly than the Fluoxetine group(P>0.005).Conclusion:Yuxing Changzhi decoction can increase NE and 5-HT levels in the brain tissue on rats with post-stroke depression significantly. |
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| Keywords: | post-stroke depression Yuxing Changzhi decoction NE 5-HT |
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