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| 嵌合抗原受体修饰免疫细胞治疗肿瘤的新策略 | |
| 引用本文： | 胡婉丽,赵嫄,张连生. 嵌合抗原受体修饰免疫细胞治疗肿瘤的新策略[J]. 中华临床医师杂志(电子版), 2014, 0(6): 1151-1154 |
| 作者姓名： | 胡婉丽 赵嫄 张连生 |
| 作者单位： | 兰州大学第二医院血液科,730030 |
| 摘 要： | 以嵌合抗原受体(CAR)为基础的细胞免疫治疗目前成为治疗恶性肿瘤的一种新兴形式。CAR技术的应用在以下几方面受到密切关注:选择合适的目标抗原;甄选高效、安全的基因转导方法;优化信号分子;筛选最具潜质的免疫细胞。随着研究的深入和技术的提高,相信CAR技术会给肿瘤患者带来福音。 |
| 关 键 词： | 肿瘤 免疫疗法 嵌合抗原受体 |
New strategies of tumor therapy by using chimeric antigen receptor-modified immunocyte |
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| Hu Wanli,Zhao Yuan,Zhang Liansheng. New strategies of tumor therapy by using chimeric antigen receptor-modified immunocyte[J]. Chinese Journal of Clinicians(Electronic Version), 2014, 0(6): 1151-1154 | |
| Authors: | Hu Wanli Zhao Yuan Zhang Liansheng |
| Affiliation: | . (Department of Hematology, Lanzhou University Second Hospital Lanzhou 730030, China) |
| Abstract: | Chimeric antigen receptor- （CAR-） based immunotherapy has been an emerging therapeutic modality for malignant tumor. It attracts close attention on choosing appropriate target antigen, filtering efficient and safe genetic modification, optimizing signal molecules, selecting good therapeutic immune cells and so on. It is believed that CAR will bring promising news to cancer patients, as the researches continue and the techniques improve. |
| Keywords: | Neoplasms lmmunotherapy Chimeric antigen receptor |
| 本文献已被 CNKI 维普 等数据库收录！ | |