pim-1与c-myc在前列腺癌中的表达及其临床意义

目的：探讨pim-1和c—myc在前列腺癌组织中的表达及与前列腺癌临床的关系。方法：采用免疫组织化学法检测pim-1和c—rnyc在良性前列腺、高等级前列腺上皮内瘤和不同分级、分期前列腺癌组织中的表达，分析pim-1和c-myc在前列腺癌中的表达及与前列腺癌临床的关系。结果：pim-1和c-myc在前列腺癌中存在明显的高表达，pim-1表达水平与前列腺癌的病理分级与临床分期呈正相关（P〈0．01）。c—myc蛋白表达水平与前列腺癌的病理分级与临床分期无明显相关性（P〉0．05）。在前列腺癌中pim-1和c—myc的表达具有相关性（P=0．001）。结论：pim-1可作为一种新的诊断前列腺癌的肿瘤标志物。pim-1和c—myc在前列腺癌中可能产生协同作用，促进前列腺癌的发生和发展。

A study on the expression of pim-1 & c-myc and their correlation in prostate cancer

Objective:To explore the expression of pim-1 and c-myc in prostate cancer and their clinical significance.Methods:Immunohistochemical stain was used to study the expression of pim-1 and c-myc in benign prostate hyperplasia,high-grade prostatic intraepithelial neoplasia and prostate cancer and their expression level were analyzed with respect to clinical relation in prostate cancer.Results:pim-1 and c-myc were highly expressed in prostate cancer.The expression of pim-1 was related significantly to the histologic grade and clinical stage of prostate cancer(P<0.01).The expression of c-myc was not related to the histologic grade and clinical stage of prostate cancer.In prostate cancer,the expression of pim-1 was related to the expression of c-myc(P<0.01).Conclusions:pim-1 may be a new diagnostic and prognostic marker of prostate cancer.pim-1 and c-myc may cooperate to promote oncogenesis and development of prostate cancer.