注射用头孢替安与注射用氯诺昔康配伍稳定性考察

目的考察注射用头孢替安与注射用氯诺昔康在0.9%氯化钠注射液中的配伍稳定性。方法在(25±1)℃下,采用HPLC法测定8 h内配伍液中头孢替安与氯诺昔康的含量变化,观察配伍液的外观,记录pH值。结果 8 h内,配伍液中氯诺昔康的含量无明显变化,头孢替安含量不断下降,8 h含量为80.8%,pH值随时间变化逐渐增大,溶液颜色随时间变化逐渐加深。结论注射用头孢替安与注射用氯诺昔康在0.9%氯化钠注射液中可配伍使用,但应在4 h内用完。

Compatible stability of cefotiam hydrochloride for injection and lornoxicam for injection in 0.9% sodium chloride injection

Objective To study the compatibility stability of cefotiam hydrochloride for injection and lornoxicam for injection in 0.9% sodium chloride injection.Methods The content of mixture solution of cefotiam hydrochloride for injection and lornoxicam in 0.9% sodium chloride injection was determined at room temperature(25±1)℃ within 8 h by HPLC,the appearance of the solution was observed,and the pH value was determined.Results No significant difference was found in content of lornoxicam in the mixture solution within 8 h,while the content of cefotiam hydrochloride decreased significantly,with 80.8% of original content at 8 h.The pH value increased,and the colors deepened gradually.Conclusion The mixture of cefotiam hydrochloride with lornoxicam in 0.9% sodium chloride injection can be used at room temperature,but it must be injected within 4 h.