依帕司他联合甲钴胺治疗高龄患者糖尿病周围神经病变

目的观察依帕司他联合甲钴胺治疗高龄患者糖尿病周围神经病变的疗效。方法选取100例确诊为糖尿病周围神经病变的高龄患者随机分为2组,治疗组50例给予依帕司他及甲钴胺治疗,对照组50例给予甲钴胺治疗,疗程12周,观察两组患者的TCSS(Toronto临床评分系统)评分及双侧MCV和SCV变化。结果治疗后,两组患者TCSS评分及双侧腓总神经传导速度(MCV和SCV)显著改善(P<0.05),但治疗组较对照组改善更明显(P<0.05)。结论依帕司他联合甲钴胺治疗高龄患者糖尿病周围神经病变临床疗效理想,且优于单药治疗。

Effect of epalrestat combined with methylcobalamin on senior's diabetic peripheral neuropathy

Objective To observe the curative effect of epalrestat combined with methylcobalamin on the senior′s diabetic peripheral neuropathy(DPN).Methods 100 senior patients with diabetic peripheral neuropathy were randomly divided into two groups.Treatment group(n=50)received epalrestat combined with methylcobalamin.Control group(n=50)received only methylcobalamin.The changes of TCSS(Toronto clinical scoring system)scores,motor and sensory nerve conduction velocity(MCV and SCV)of bilateral common peroneal nerve after 12 weeks were analyzed.Results After treatment,TCSS scores and conduction velocity(MCV and SCV)of bilateral common peroneal nerve of the 2 groups were obviously improved(P<0.05),and significant differences were observed between the 2 groups(P<0.05).Conclusion Epalrestat combined with methylcobalamin has ideal clinical curative effect on senior′s diabetic peripheral neuropathy,and it is superior to single drug treatment.