Gd-DTPA 增强 MRI 胸部组织序列信号变化的临床研究

目的：通过对肺癌和正常胸部组织的Ｇｄ－ＤＴＰＡ增强前后的信号强度、信噪比和相对信噪比的分析，探讨增强ＭＲ在胸部的应用价值。方法：用ＤＩＡＳＯＮＩＣ０．３５Ｔｅｓｌａ超导型ＭＲ成像仪。先常规平扫Ｔ１ＷＩ、Ｔ２ＷＩ，然后按０．１ｍｍｏｌ／ｋｇ体重，静脉内一次性注入Ｇｄ－ＤＴＰＡ（维影钆胺注射液）。立即行兴趣部位Ｔ１ＷＩ扫描。计算机测量病变及对照组织（皮下脂肪、肌肉、肺野及噪声）的信号强度，计算其信噪比（ＳＮＲ）和相对信噪比（ＣＮＲ）。结果：２９例支气管肺癌平均信号强度明显高于对照组织（Ｐ＜０．０１），增强后Ｔ１ＷＩ的ＳＮＲ明显高于平扫Ｔ１ＷＩ和Ｔ２ＷＩ；ＣＮＲ（以肌肉为对照）则高于平扫Ｔ１ＷＩ，与Ｔ２ＷＩ相似；与脂肪为参照物则与平扫Ｔ１ＷＩ、Ｔ２ＷＩ相似；以肺野为参照物则与Ｔ１ＷＩ相似，明显高于Ｔ２ＷＩ。结论：支气管肺癌增强后较对照组织有明显的强化；增强后Ｔ１ＷＩ可显著提高ＭＲ的信噪比，改善图像质量。ＭＲ造影剂在胸部有一定的应用价值

GD-DTPA-Enhanced MRI of Thoracic Tissue-Clinical Study

Objective:This study evaluated the effect of Gd-DTPA on enhancement of thoracic masses and reference tissue.Gadolinium DTPA injection was administered intravenously at a dose of 0.1mmol/kg to 29 cases with thoracic masses using DIASONIC 0.35 Tesla superconductive MRI.T 1WI,T 2WI were obtained respectively before and after contrast medium injection,the thoracic masses and reference tissue were caculated automaticly,and image quality were qualitified by measuring signal-to-noise ratio(SNR)and contrast-to-noise ratio(CNR).Results:The signal intensity of bronchogenic carcinoma was significantly higher than refrence tissue.SNR of the masses increased significantly(P<0.01)on postcontrast T 1WI than on precontrast T 1WI and T 2WI.The CNR (refrence tissue muscle) improved significantly (P<0.01) after contrast medium injection.However,there was no significantly difference in CNR to precontrast T 2WI.When fat was used as reference tissue,CNR of the thoracic masses decreased significantly.Conclusion:This study shows that Gd-DTPA caused significantly enhancement of thoracic masses on T 1WI.It may improve MR images quality and so have some degree value in thoracic disease.