质子泵抑制剂合理用药分析及专项整治工作建议

目的：回顾性分析我院住院患者2016年质子泵抑制剂（PPIs）的使用情况,了解PPIs在我院的合理应用情况,针对PPIs专项整治活动的开展提出建议。方法：调取2016年住院患者PPIs用药数据,包括药品名称、使用金额、临床诊断、用法用量、疗程、使用人数等,并对PPIs使用率排名前10位的临床科室随机抽取500份病历（50份/科）进行用药合理性分析。结果：我院PPIs的不合理使用存在的主要问题有无指征用药、品种选择不当、疗程过长、用法用量不合理、存在药物相互作用等。结论：应尽快开展PPIs专项整治活动。由行政部门制定点评方案并实施;由药剂科临床药学室具体开展PPIs专项整治工作,确定评价内容和抽检病历方案,并对不合理病历进行干预和点评后再干预工作;在PPIs专项整治工作早期开展宣传和培训工作,以期推动我院PPIs的合理应用。

Analysis of Rational Use of Proton Pump Inhibitors and Suggestions for Special Rectification

Objective: To retrospectively analyze the application of proton pump inhibitors (PPIs) of inpatients in our hospital in 2016, to understand the situation of the rational use of PPIs, and to put forward Suggestions for the special rectifcation for PPIs. Methods: Data concerning the medication of PPIs of inpatients including drug name, amount of use, clinical diagnosis, usage and dosage, medical course, and number of users, etc. were collected. 500 medical records (50 per department) were randomly selected from the top 10 clinical departments by using PPIs and the rational use of PPIs was analyzed. Results: The main problem of the irrational use of PPIs consisted of medication without indication, inappropriate variety selection, long medical course, unreasonable usage and dosage as well as drug interactions. Conclusion: The special rectifcation for PPIs should be carried out as soon as possible. The review plan should be formulated and implemented by administrative departments. The special rectification work should be carried out by the division of clinical pharmacy of the department of pharmacy, such as the confrmation of evaluation content and the plan of sampling the medical records, reviewing the unreasonable medical records and the reevaluation. The publicity and training work should be carried out in the early stage of the special rectifcation in order to promote rational use of PPIs.