高比容多糖治疗便秘合并血糖升高患者的研究

目的 观察高比容多糖对便秘伴空腹血糖受损及便秘伴糖尿病患者的治疗作用及其对血糖的影响。方法 选择便秘伴空腹血糖受损患者80 例，便秘并发糖尿病患者60 例，分别给予高比容多糖制剂15 g/d，分3 次口服，治疗14 d。记录服药前后两组患者粪便分型、排便费力感、排便不尽或下坠胀感、肛门直肠阻塞感及高比容多糖对便秘患者空腹血糖、血糖波动值的影响。结果 两组患者均获随访，服药期间无不良反应发生。治疗后7、14 d 便秘合并空腹血糖受损组及便秘合并糖尿病组患者粪便分型、排便费力感、排便不尽或下坠胀感、肛门直肠阻塞感等情况与治疗前比较均获得明显改善，差异有统计学意义（P <0.05）；便秘合并空腹血糖受损患者应用高比容多糖后空腹血糖及血糖波动值与治疗前比较均下降，差异有统计学意义（P <0.05）。便秘合并糖尿病患者血糖波动值从（4.14±1.62）mmol/L 下降为（3.60±1.72）mmol/L，差异有统计学意义（P <0.05）。结论高比容多糖对便秘合并空腹血糖受损或糖尿病患者的便秘疗效确切，安全无副作用；对便秘合并空腹血糖受损患者的空腹血糖及血糖波动值有降低和平稳作用；对便秘合并糖尿病患者的空腹血糖无下降作用，但对血糖波动值有平稳作用。

Efficacy and safety of high specific volume polysaccharide fortreatment of constipation with IFG or DM

Objective To observe the effect of high specific volume polysaccharide, a new kind of dietary fiber,for the treatment of constipation in the patients with impaired fasting glucose (IFG) or diabetes, and its impact onblood sugar. Methods In this study, 80 constipation patients with IFG (IFG group) and 60 constipation patients withdiabetes (DM group) were enrolled. To relieve their symptoms, the subjects were administrated with high specificvolume polysaccharide 5 g, three times daily, for 2 w. The stool form, exertion in defecation, feeling of incompletedefecation, and feeling of anorectal blocking were recorded before and after administration. The average fasting bloodglucose levels and the mean amplitude of glycemic excursions in both groups were also recorded. Moreover, theadverse reactions were observed. Results Every volunteer returned for a follow-up visit. No adverse reactions werereported in either group. In both groups, the stool form, straining during a bowel movement, feeling of incompletebowel movement and feeling of blocking anorectum were relieved after treatment for 7 and 14 d (P < 0.05). In theIFG group, both the average fasting blood glucose level and the mean amplitude of glycemic excursions dropped afteradministration. In the DM group, the mean amplitude of glycemic excursions dropped from (4.14 ± 1.62) mmol/L to(3.60 ± 1.72) mmol/L (P < 0.05). Conclusions High specific volume polysaccharide has been proved to be effective and safe in the treatment of constipation without adverse reactions. It can decrease and stabilize the blood sugar level and the fluctuation of blood sugar in the constipation patients with impaired fasting blood glucose, however only stabilize blood sugar fluctuation in the constipation patients with diabetes.